Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | INPPL1 | O15357 | 9/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL488537 | 0.82 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| 2-Aminopyridine SCHEMBL27630019 | 0.78 | MEN1 (0.49) | MEN1KMT2AMET | |
| SCHEMBL487679 | 0.77 | MET (0.57) | MET | |
| SCHEMBL10215935 | 0.72 | MAP4K4 (0.44) | MET | |
| SCHEMBL30453168 | 0.71 | JAK2 (0.60) | METCYP11B1CYP11B2 | |
| SCHEMBL4639245 | 0.71 | MAOB (0.51) | MEN1KMT2A | |
| SCHEMBL30423385 | 0.70 | CYP11B1 (0.59) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL30452799 | 0.68 | MET (0.52) | MET | |
| SCHEMBL488590 | 0.68 | JAK2 (0.51) | INPPL1MET | |
| SCHEMBL5583002 | 0.68 | MAPK1 (0.56) | CHRNB2CHRNA4MEN1KMT2ACHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106197-B2 | Aminoheteroaryl compounds as protein kinase inhibitors | PFIZER INC. (US) | 2012-01-31 | — | — | US | disclosed |
| US-20070072874-A1 | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN, INC. | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072874-A1 | Aminoheteroaryl compounds as protein kinase inhibitors | MET, MAP4K1, MAP4K2 | CHRNB2 4036/4885CHRNA4 4469/4885INPPL1 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.