Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.59 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NT5E | P21589 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.54 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13373355 | 0.85 | PIM1 (0.70) | KDM4EL3MBTL1GAAPIM1PIM3 | |
| SCHEMBL601922 | 0.84 | ROCK1 (0.59) | KDM4EL3MBTL1PIM1PIM3PIM2 | |
| SCHEMBL20577434 | 0.83 | PIM1 (0.52) | KDM4EL3MBTL1GAAPIM1PIM3 | |
| SCHEMBL18843417 | 0.81 | NPC1 (0.57) | ROCK1KMT2APOLBMEN1NPC1 | |
| SCHEMBL28304288 | 0.81 | RAB9A (0.62) | KDM4EPIM1PIM3PIM2ROCK1 | |
| SCHEMBL1898755 | 0.79 | GAA (0.91) | KDM4EL3MBTL1GAAJAK2TYK2 | |
| SCHEMBL14716526 | 0.79 | KDM4E (1.00) | KDM4EL3MBTL1GAAJAK2TYK2 | |
| SCHEMBL19774543 | 0.77 | KDM4E (0.80) | KDM4EL3MBTL1GAAJAK2TYK2 | |
| SCHEMBL16416801 | 0.77 | KDM4E (0.67) | KDM4EL3MBTL1GAAJAK2TYK2 | |
| SCHEMBL17159814 | 0.77 | PIM1 (0.69) | KDM4EL3MBTL1GAAPIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | ICAGEN, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| US-7223782-B2 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-20050049237-A1 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2005-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | SCN3A, TRPV3, HCN3 | KDM4E 2869/4885L3MBTL1 4714/4885GAA 4722/4885 |
| US-20050049237-A1 | Pyrazole-amides and -sulfonamides | SCN3A, TRPV3, HCN3 | KDM4E 2869/4885L3MBTL1 4714/4885GAA 4722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.