Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 2/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.48 |
| ▸ | TDP2 | O95551 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6253369 | 0.98 | HSD17B3 (0.51) | HSD17B3CYP11B1CYP11B2TDP2PARP10 | |
| SCHEMBL21028472 | 0.93 | HSD17B3 (0.49) | HSD17B3CYP11B1CYP11B2TDP2PARP10 | |
| SCHEMBL27445644 | 0.88 | CYP11B1 (0.56) | HSD17B3CYP11B1CYP11B2TDP2PARP10 | |
| SCHEMBL9845507 | 0.88 | CYP11B1 (0.61) | HSD17B3CYP11B1CYP11B2TDP2PARP10 | |
| SCHEMBL30125264 | 0.88 | CYP11B1 (0.56) | HSD17B3CYP11B1CYP11B2TDP2PARP10 | |
| SCHEMBL20079881 | 0.85 | CYP11B1 (0.52) | HSD17B3CYP11B1CYP11B2TDP2PARP10 | |
| SCHEMBL14618924 | 0.82 | TDP2 (0.46) | HSD17B3CYP11B1CYP11B2TDP2PARP10 | |
| SCHEMBL14618928 | 0.82 | TDP2 (0.46) | HSD17B3CYP11B1CYP11B2TDP2PARP10 | |
| SCHEMBL4970944 | 0.80 | CYP1A2 (0.67) | HSD17B3CYP11B1CYP11B2TDP2PARP10 | |
| SCHEMBL27806355 | 0.80 | CYP2A6 (0.59) | HSD17B3CYP11B1CYP11B2TDP2PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214845-A1 | ANTIBACTERIAL 6'-MODIFIED 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS | ISIS PHARMACEUTICALS, INC. (US) | 2008-09-04 | — | — | US | disclosed |
| WO-2007028012-A2 | ANTIBACTERIAL 6'-N-MODIFIED 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS | ISIS PHARMACEUTICALS, INC. (US) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214845-A1 | ANTIBACTERIAL 6'-MODIFIED 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS | FUT6, ALG8, NRDC | HSD17B3 4746/4885CYP11B1 4490/4885CYP11B2 4460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.