Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | PDE8B | O95263 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075051 | 0.76 | MAPK13 (0.41) | — | |
| SCHEMBL4889103 | 0.76 | IGF1R (0.39) | — | |
| SCHEMBL4473387 | 0.71 | DHFR (0.35) | HRH4PDE8BHRH3 | |
| SCHEMBL1771300 | 0.70 | NPC1 (0.39) | — | |
| SCHEMBL4469628 | 0.70 | ADORA2A (0.41) | PDE8BADORA2AADORA1 | |
| SCHEMBL16637163 | 0.65 | ALOX15 (0.41) | — | |
| SCHEMBL30782745 | 0.65 | HRH4 (0.40) | HRH4ADORA2AADORA1HRH3 | |
| SCHEMBL25338891 | 0.63 | ALDH1A1 (0.42) | — | |
| SCHEMBL4458641 | 0.63 | HCAR2 (0.42) | — | |
| SCHEMBL170833 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |