Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12875617 | 0.87 | MAPT (0.54) | MAPTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL4897248 | 0.83 | KDM4E (0.46) | MAPTCYP3A4ALDH1A1KMT2AHPGD | |
| SCHEMBL7232953 | 0.80 | MAPK1 (0.51) | MAPTPPARGNCOA2NCOA1ALDH1A1 | |
| SCHEMBL4859662 | 0.77 | SPR (0.52) | MAPTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL7157437 | 0.76 | KDM4E (0.40) | MAPTCYP3A4ALDH1A1KMT2AHPGD | |
| SCHEMBL4896499 | 0.75 | SNCA (0.40) | MAPTCYP3A4PPARGALDH1A1KMT2A | |
| SCHEMBL12890284 | 0.72 | HPGD (0.60) | MAPTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL562666 | 0.65 | ALDH1A1 (0.50) | CYP3A4ALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL10394651 | 0.65 | ALDH1A1 (0.41) | CYP3A4ALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL15168064 | 0.65 | HTT (0.45) | MAPTALDH1A1KMT2AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |
| US-20050215608-A1 | Bis-aryl thiazole derivatives | AMGEN INC. | 2005-09-29 | — | — | US | disclosed |
| WO-2003002062-A2 | BIS-ARYL THIAZOLE DERIVATIVES | TULARIK INC. (US) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215608-A1 | Bis-aryl thiazole derivatives | FABP4, PC, TXNRD2 | MAPT 1292/4885CYP3A4 2708/4885PPARG 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.