Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 6/20 | 0.56 |
| ▸ | PNP | P00491 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 5/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364441 | 0.89 | HPRT1 (0.60) | HPRT1PNPNOS1NOS3NOS2 | |
| SCHEMBL571646 | 0.85 | HPRT1 (0.60) | HPRT1PNPNOS1 | |
| SCHEMBL3836268 | 0.84 | HPRT1 (0.61) | HPRT1PNPNOS1NOS3NOS2 | |
| SCHEMBL3793007 | 0.84 | HPRT1 (0.58) | HPRT1PNPNOS1NOS3NOS2 | |
| SCHEMBL3743947 | 0.83 | HPRT1 (0.56) | HPRT1NOS1KMT2AALDH1A1NOS3 | |
| SCHEMBL9515983 | 0.83 | HPRT1 (0.72) | HPRT1PNP | |
| SCHEMBL6061495 | 0.82 | HPRT1 (0.58) | HPRT1PNPNOS1 | |
| SCHEMBL9662657 | 0.82 | HPRT1 (0.56) | HPRT1NOS1NOS3NOS2 | |
| SCHEMBL9513457 | 0.80 | HPRT1 (0.49) | HPRT1PNPNOS1 | |
| SCHEMBL9514656 | 0.79 | HPRT1 (0.56) | HPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101460178-B | Immune regulative RNA (SIMRA) compound for the stabilisation of TLR7 and TLR8 | 艾德拉药物股份有限公司 | 2016-12-07 | — | — | CN | claimed |
| US-9243050-B2 | Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8 | Idera Pharamaceuticals, Inc. (US) | 2016-01-26 | — | — | US | claimed |
| EP-2021008-B1 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | IDERA PHARMACEUTICALS INC (US) | 2015-12-02 | — | — | EP | claimed |
| EP-1934239-B1 | IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE | IDERA PHARMACEUTICALS INC (US) | 2015-07-15 | — | — | EP | claimed |
| US-20140308300-A1 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | NOVAQUEST CO-INVESTMENT FUND XV, L.P. | 2014-10-16 | — | — | US | claimed |
| US-8853375-B2 | Toll like receptor modulators | IDERA PHARMACEUTICALS, INC. (US) | 2014-10-07 | — | — | US | claimed |
| US-8759310-B2 | Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8 | IDERA PHARMACEUTICALS, INC. (US) | 2014-06-24 | — | — | US | claimed |
| US-20130202584-A1 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | IDERA PHARMACEUTICALS, INC. | 2013-08-08 | — | — | US | claimed |
| US-8106173-B2 | Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8 | IDERA PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | claimed |
| JP-2009533348-A | — | — | 2009-09-17 | — | — | JP | claimed |
| CN-101460178-A | Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8 | IDERA PHARMACEUTICALS INC (US) | 2009-06-17 | — | — | CN | claimed |
| EP-2021008-A2 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | Idera Pharmaceuticals, Inc. (US) | 2009-02-11 | — | — | EP | claimed |
| US-20080171712-A1 | At least two oligonucleotides having modified purine bases, such as deazaguanosines or deaza-adenosines, linked by an alkyl or phenolic diol or triol; vaccines, DNA vaccines; anticarcinogenic, antiallergenic, antiinflammatory agents; bronchodilators | IDERA PHARMACEUTICALS, INC. | 2008-07-17 | — | — | US | claimed |
| WO-2007117686-A2 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | IDERA PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | claimed |
| EP-4323525-A2 | OPTIMIZED TLR7 LIGANDS AND USES THEREOF | Genentech, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |
| US-20240042019-A1 | OPTIMIZED TLR7 LIGANDS AND USES THEREOF | GENENTECH INC (US) | 2024-02-08 | — | — | US | disclosed |
| CN-117203340-A | Optimized TLR7 ligands and uses thereof | 基因泰克公司 | 2023-12-08 | — | — | CN | disclosed |
| WO-2007047396-A2 | IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE | IDERA PHARMACEUTICALS, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
| WO-2005016235-A2 | COMBINED USE OF IMPDH INHIBITORS WITH TOLL-LIKE RECEPTOR AGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-02-24 | — | — | WO | disclosed |
| US-20050004144-A1 | Combined use of IMPDH inhibitors with toll-like receptor agonists | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004144-A1 | Combined use of IMPDH inhibitors with toll-like receptor agonists | IMPDH1, TLR3, IMPDH2 | HPRT1 73/4885PNP 55/4885NOS1 761/4885 |
| US-20080171712-A1 | At least two oligonucleotides having modified purine bases, such as deazaguanosines or deaza-adenosines, linked by an alkyl or phenolic diol or triol; vaccines, DNA vaccines; anticarcinogenic, antiallergenic, antiinflammatory agents; bronchodilators | TLR8, TLR7, TLR9 | HPRT1 596/4885PNP 46/4885NOS1 1917/4885 |
| US-20130202584-A1 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | TLR8, TLR7, TLR9 | HPRT1 913/4885PNP 406/4885NOS1 2775/4885 |
| US-20140308300-A1 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | TLR8, TLR7, TLR9 | HPRT1 913/4885PNP 406/4885NOS1 2775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.