Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CES2 | O00748 | 2/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11226078 | 0.91 | CHRNB2 (0.35) | KMT2AMAPTCA1CHRNB2CHRNB4 | |
| SCHEMBL105813 | 0.82 | MAPT (0.41) | KMT2AMAPTTSHRCES2CES1 | |
| SCHEMBL27694927 | 0.79 | KMT2A (0.55) | KMT2AMAPTTSHRCES2CES1 | |
| SCHEMBL27695572 | 0.79 | KMT2A (0.55) | KMT2AMAPTTSHRCES2CES1 | |
| SCHEMBL20838326 | 0.78 | MAPT (0.39) | KMT2AMAPTTSHRCES2CES1 | |
| SCHEMBL11451286 | 0.77 | CYP1A2 (0.43) | KMT2AMAPTTSHRALDH1A1LMNA | |
| SCHEMBL9853471 | 0.76 | CA1 (0.36) | ALDH1A1CA1 | |
| SCHEMBL26105510 | 0.76 | KMT2A (0.45) | KMT2AMAPTCES2CES1ALDH1A1 | |
| SCHEMBL5194043 | 0.75 | KMT2A (0.59) | KMT2AMAPTTSHRCES2CES1 | |
| SCHEMBL16663701 | 0.75 | MAPT (0.52) | KMT2AMAPTTSHRCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432271-B2 | Pyrazolyl inhibitors of 15-lipoxygenase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-07 | — | — | US | disclosed |
| US-7351727-B2 | Inhibitors of 15-lipoxygenase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-04-01 | — | — | US | disclosed |
| US-20050070589-A1 | Pyrazolyl inhibitors of 15- lipoxygenase | BRISTOL-MYERS SQUIBB COMPANY | 2005-03-31 | — | — | US | disclosed |
| US-20050065198-A1 | Inhibitors of 15-lipoxygenase | BRISTOL-MYERS SQUIBB COMPANY | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070589-A1 | Pyrazolyl inhibitors of 15- lipoxygenase | ALOX15, ALOX5, ALOX15B | KMT2A 3648/4885MAPT 4047/4885TSHR 3875/4885 |
| US-20050065198-A1 | Inhibitors of 15-lipoxygenase | ALOX15, ALOX5, ALOX15B | KMT2A 3206/4885MAPT 4250/4885TSHR 3036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.