SCHEMBL4894350

SCHEMBL4894350

C=C1CC(=O)N(c2ccc(Cl)cc2)C1=O

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 7/20 0.54
KMT2A Q03164 7/20 0.54
MGLL Q99685 1/20 0.47
ALDH1A1 P00352 4/20 0.44
LMNA P02545 2/20 0.44
ELANE P08246 2/20 0.43
POLB P06746 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
MAPT P10636 3/20 0.41
HTT P42858 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
CASP6 P55212 1/20 0.40
RAD51 Q06609 1/20 0.40
ALOX12 P18054 1/20 0.40
KDM4E B2RXH2 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL237914 0.90 GAA (0.44) MEN1KMT2AMGLLALDH1A1LMNA
SCHEMBL11067327 0.83 ALDH1A1 (0.43) MEN1KMT2AALDH1A1MAPTCASP6
SCHEMBL2983688 0.81 GAA (0.57) MEN1KMT2AMGLLALDH1A1LMNA
SCHEMBL4443303 0.81 MGLL (0.56) MEN1KMT2AMGLLALDH1A1LMNA
SCHEMBL225820 0.81 GAA (0.58) MEN1KMT2AMGLLALDH1A1L3MBTL1
SCHEMBL7932608 0.80 MGLL (0.48) MEN1KMT2AMGLLALDH1A1LMNA
SCHEMBL24741188 0.79 ALDH1A1 (0.38) MEN1KMT2AALDH1A1LMNAPOLB
SCHEMBL12317338 0.79 TRIM24 (0.42) MEN1KMT2AALDH1A1POLBL3MBTL1
SCHEMBL22728447 0.78 BCHE (0.47) MEN1KMT2AALDH1A1LMNAKDM4E
SCHEMBL8123624 0.76 MEN1 (0.61) MEN1KMT2AMGLLALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240209166-A1 RESIN COMPOSITION FOR NON-CONDUCTIVE FILM WITH EXCELLENT HIGH TEMPERATURE PROPERTIES FOR 3D TSV PACKAGES HENKEL AG & CO KGAA (DE) 2024-06-27 US disclosed
US-20080003288-A1 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2008-01-03 US disclosed
US-7204997-B2 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2007-04-17 US disclosed
EP-1478403-A1 RESPONSIVE MICROGEL AND METHODS RELATED THERETO SUPRATEK PHARMA, INC. (CA) 2004-11-24 EP disclosed
US-20030152623-A1 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2003-08-14 US disclosed
WO-2003063909-A1 RESPONSIVE MICROGEL AND METHODS RELATED THERETO SUPRATEK PHARMA INC. (US) 2003-08-07 WO disclosed
US-6491903-B1 NARROW MOLECULAR WEIGHT DISTRIBUTION SHELL-CORE POLYMERS HAVING HYDROPHILIC, CROSSLINKED PERMEABLE SHELLS AND HYDROPHOBIC CORES, USED FOR REDUCING BLOOD CHOLESTEROL AND BILE ACID UPTAKE IN INTERSTINES; DRUG DELIVERY WASHINGTON UNIVERSITY 2002-12-10 US disclosed
EP-0910351-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. Searle & Co. (US) 1999-04-28 EP disclosed
WO-1997049387-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. SEARLE AND CO. (US) 1997-12-31 WO disclosed
US-4847285-A 1-substituted phenyl-3-substituted methyl-pyrrolidine-2,5-diones and plant fungicide compositions containing same THE DOW CHEMICAL COMPANY (US) 1989-07-11 US disclosed
EP-0173284-A1 Substituted 1-phenyl-3-methyl-pyrrolidindiones, their manufacture and use as fungicides THE DOW CHEMICAL COMPANY (US) 1986-03-05 EP disclosed