Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | CA7 | P43166 | 3/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27723279 | 0.98 | CYP2C9 (0.61) | CYP2C9CYP2C19CA12CA1CA2 | |
| Biphenyl SCHEMBL27470971 | 0.88 | CYP2C9 (0.55) | CYP2C9CYP2C19CYP1A2LMNAALDH1A1 | |
| SCHEMBL13531222 | 0.84 | LMNA (0.56) | CYP2C9CYP2C19ESR1CYP1A2LMNA | |
| Hydrochloric Acid SCHEMBL27726302 | 0.83 | SOAT1 (0.47) | CYP2C9CYP2C19CA12CA1CA2 | |
| SCHEMBL277284 | 0.83 | CYP2C19 (0.86) | CYP2C9CYP2C19CA12CA1CA2 | |
| SCHEMBL2998358 | 0.82 | CA12 (0.56) | CYP2C9CYP2C19CA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL9679507 | 0.82 | CYP2C19 (0.83) | CYP2C9CYP2C19CA12CA1CA2 | |
| SCHEMBL27810926 | 0.81 | L3MBTL1 (0.67) | CYP2C9CYP2C19ESR1CYP1A2LMNA | |
| SCHEMBL28261662 | 0.80 | LMNA (0.66) | CYP2C9CYP2C19ESR1CYP1A2LMNA | |
| SCHEMBL19779521 | 0.79 | VNN1 (0.57) | CYP2C9CYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 232 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831060-A1 | NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2015-02-04 | — | — | EP | claimed |
| WO-2013144129-A1 | NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2013-10-03 | — | — | WO | claimed |
| CN-101675060-A | Substituted dihydro and tetrahydro oxazolopyrimidinones, their preparation and use | SANOFI AVENTIS | 2010-03-17 | — | — | CN | claimed |
| CN-1181057-C | Novel 5-pyrimidine carboxamide derivatives and the pharmaceutical compositions containing said derivatives | ����ҩƷ��ҵ��ʽ���� | 2004-12-22 | — | — | CN | claimed |
| US-6762189-B1 | HEPATITIS B VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS ANTIPROLIFERATION AGENTS; REDUCED CHANCE OF TOXICITY, SIDE EFFECTS, AND DEVELOPMENT OF RESISTANT VIRAL STRAINS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2004-07-13 | — | — | US | claimed |
| CN-1507447-A | Substituted pyrazolopyrimidines and thiazolopyrimidines | — | 2004-06-23 | — | — | CN | claimed |
| EP-1235806-A4 | NOVEL 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | DONG WHA PHARM IND CO LTD (KR) | 2004-02-04 | — | — | EP | claimed |
| CN-1390203-A | Novel 5-pyrimidine carboxamide derivatives and the pharmaceutical compositions containing said derivatives | DONG WHA PHARM IND CO LTD (KR) | 2003-01-08 | — | — | CN | claimed |
| EP-1235806-A1 | NOVEL 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD. (KR) | 2002-09-04 | — | — | EP | claimed |
| WO-2001038308-A1 | NOVEL 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | DONG WHA PHARM. IND. CO., LTD (KR) | 2001-05-31 | — | — | WO | claimed |
| CN-119855815-A | KRAS mutant protein inhibitor, and preparation method and application thereof | 甘李药业股份有限公司 | 2025-04-18 | — | — | CN | disclosed |
| CN-119569743-A | Compound based on 6-methylfuro [2,3-d ] pyrimidine-4 (3H) -ketone structure, and preparation method and application thereof | 沈阳药科大学 | 2025-03-07 | — | — | CN | disclosed |
| CN-119285628-A | Compounds for the treatment and prophylaxis of respiratory syncytial virus infection diseases | 石药集团中奇制药技术（石家庄）有限公司 | 2025-01-10 | — | — | CN | disclosed |
| CN-118922188-A | Pyrimidine and methods of use thereof | 奇尼塔公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-113412113-B | Amino oxazinamides | 豪夫迈·罗氏有限公司 | 2024-07-26 | — | — | CN | disclosed |
| WO-2001016107-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2001-03-08 | — | — | WO | disclosed |
| US-4898868-A | ANTICHOLESTEROL AGENTS; LACTONE OR FREE ACID FORM | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-02-06 | — | — | US | disclosed |
| US-4144339-A | TREATMENT OF BILHARZIASIS | RHONE-POULENC INDUSTRIES (FR) | 1979-03-13 | — | — | US | disclosed |
| US-4138487-A | NEMATOCIDES | RHONE-POULENC INDUSTRIES (FR) | 1979-02-06 | — | — | US | disclosed |
| US-4110450-A | BILHARZIASIS | RHONE-POULENC INDUSTRIES (FR) | 1978-08-29 | — | — | US | disclosed |