Sugi Predict

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SCHEMBL4895764

SCHEMBL4895764

COC(=O)c1cc(S(=O)(=O)NCCc2ccc(OCc3ccc(Cl)cc3)cc2)ccc1C

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.54
▸ LMNA P02545 4/20 0.52
▸ TP53 P04637 3/20 0.52
▸ SGMS1 Q86VZ5 2/20 0.51
▸ F2 P00734 1/20 0.51
▸ PLG P00747 1/20 0.51
▸ TBXA2R P21731 1/20 0.49
▸ PPARG P37231 1/20 0.48
▸ AKR1C3 P42330 1/20 0.48
▸ ALDH1A1 P00352 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48
▸ MEN1 O00255 2/20 0.48
▸ KMT2A Q03164 2/20 0.48
▸ NPSR1 Q6W5P4 1/20 0.48
▸ NPC1 O15118 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ RECQL P46063 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4907013 0.92 AKR1C3 (0.53) MAPTLMNATP53SGMS1F2
SCHEMBL4902960 0.92 ALDH1A1 (0.53) MAPTLMNATP53SGMS1TBXA2R
SCHEMBL4905124 0.91 ALDH1A1 (0.55) MAPTLMNATP53SGMS1TBXA2R
SCHEMBL4895834 0.91 MAPT (0.56) MAPTLMNATP53SGMS1TBXA2R
SCHEMBL4904019 0.90 ALDH1A1 (0.57) MAPTLMNATP53SGMS1AKR1C3
SCHEMBL4904196 0.89 ALDH1A1 (0.49) MAPTLMNATP53SGMS1TBXA2R
SCHEMBL4899302 0.89 MAPT (0.57) MAPTLMNATP53TBXA2RAKR1C3
SCHEMBL4906442 0.88 MAPT (0.50) MAPTLMNATP53TBXA2RAKR1C3
SCHEMBL4899749 0.87 ERBB2 (0.50) MAPTTBXA2RAKR1C3ALDH1A1SMN1; SMN2
SCHEMBL4906213 0.87 MMP2 (0.53) MAPTLMNATP53SGMS1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
EP-1765796-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS Pfizer Products Inc. (US) 2007-03-28 — — EP disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
WO-2006003495-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER PRODUCTS INC. (US) 2006-01-12 — — WO disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD MAPT 1858/4885LMNA 317/4885TP53 3260/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD MAPT 1786/4885LMNA 319/4885TP53 3421/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD MAPT 1786/4885LMNA 319/4885TP53 3421/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.