Sugi Predict

Sugi Predict / Compounds / SCHEMBL4905124

SCHEMBL4905124

SCHEMBL4905124

COC(=O)c1cc(S(=O)(=O)NCCc2ccc(OCc3ccccc3)cc2)ccc1C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.55
▸ POLB P06746 1/20 0.55
▸ SGMS1 Q86VZ5 8/20 0.54
▸ TBXA2R P21731 1/20 0.54
▸ TBXAS1 P24557 1/20 0.54
▸ MEN1 O00255 1/20 0.53
▸ GAA P10253 1/20 0.53
▸ KMT2A Q03164 1/20 0.53
▸ AKR1C3 P42330 1/20 0.52
▸ TP53 P04637 1/20 0.52
▸ MAPT P10636 2/20 0.50
▸ ADAMTS4 O75173 1/20 0.50
▸ MMP1 P03956 1/20 0.50
▸ MMP2 P08253 1/20 0.50
▸ MMP9 P14780 1/20 0.50
▸ MMP13 P45452 1/20 0.50
▸ MMP14 P50281 1/20 0.50
▸ ADAM17 P78536 1/20 0.50
▸ ADAMTS5 Q9UNA0 1/20 0.50
▸ LMNA P02545 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4902960 0.93 ALDH1A1 (0.53) ALDH1A1SGMS1TBXA2RTBXAS1MEN1
SCHEMBL4905979 0.93 LMNA (0.57) ALDH1A1POLBSGMS1TBXA2RTBXAS1
SCHEMBL4904019 0.91 ALDH1A1 (0.57) ALDH1A1POLBSGMS1KMT2AAKR1C3
SCHEMBL4895764 0.91 MAPT (0.54) ALDH1A1SGMS1TBXA2RMEN1KMT2A
SCHEMBL4909535 0.91 TDP1 (0.57) ALDH1A1MEN1KMT2AADAMTS4MMP1
SCHEMBL4904196 0.90 ALDH1A1 (0.49) ALDH1A1SGMS1TBXA2RTBXAS1MEN1
SCHEMBL4903809 0.89 ALDH1A1 (0.55) ALDH1A1POLBSGMS1TBXA2RTBXAS1
SCHEMBL4899749 0.88 ERBB2 (0.50) ALDH1A1TBXA2RTBXAS1AKR1C3MAPT
SCHEMBL4906213 0.88 MMP2 (0.53) ALDH1A1POLBSGMS1TBXA2RTBXAS1
SCHEMBL4906442 0.87 MAPT (0.50) ALDH1A1TBXA2RTBXAS1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD ALDH1A1 2664/4885POLB 1488/4885SGMS1 226/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD ALDH1A1 2956/4885POLB 1807/4885SGMS1 260/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD ALDH1A1 2956/4885POLB 1807/4885SGMS1 260/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.