Sugi Predict

Sugi Predict / Compounds / SCHEMBL4899749

SCHEMBL4899749

SCHEMBL4899749

COC(=O)c1cc(S(=O)(=O)NCCc2ccc(OCc3ccc(C(F)(F)F)cc3)cc2)ccc1C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ERBB2 P04626 2/20 0.50
▸ ERBB4 Q15303 2/20 0.50
▸ ADAMTS4 O75173 1/20 0.48
▸ MMP13 P45452 1/20 0.48
▸ MMP1 P03956 1/20 0.46
▸ MMP2 P08253 1/20 0.46
▸ MMP9 P14780 1/20 0.46
▸ MMP14 P50281 1/20 0.46
▸ ADAM17 P78536 1/20 0.46
▸ MAOB P27338 2/20 0.46
▸ ALDH1A1 P00352 2/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ AR P10275 1/20 0.45
▸ PKM P14618 1/20 0.44
▸ MAPK1 P28482 1/20 0.44
▸ HTT P42858 1/20 0.44
▸ AKR1C3 P42330 1/20 0.44
▸ BCL2L1 Q07817 1/20 0.44
▸ MCL1 Q07820 1/20 0.44
▸ MAPT P10636 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4905297 0.93 ADAMTS4 (0.50) ERBB2ERBB4ADAMTS4MMP13MMP1
SCHEMBL4906499 0.91 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2PKMMAPK1HTT
SCHEMBL4904384 0.91 ERBB2 (0.49) ERBB2ERBB4ADAMTS4MMP13MMP1
SCHEMBL4894408 0.91 ERBB2 (0.51) ERBB2ERBB4ADAMTS4MMP13MMP1
SCHEMBL4904019 0.89 ALDH1A1 (0.57) ERBB2ERBB4ADAMTS4MMP1MMP2
SCHEMBL4894513 0.89 HTT (0.48) ERBB2ERBB4ALDH1A1SMN1; SMN2PKM
SCHEMBL4902960 0.89 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2PKMMAPK1HTT
SCHEMBL4905124 0.88 ALDH1A1 (0.55) ADAMTS4MMP13MMP1MMP2MMP9
SCHEMBL4895764 0.87 MAPT (0.54) ALDH1A1SMN1; SMN2AKR1C3MAPTTBXA2R
SCHEMBL4906213 0.87 MMP2 (0.53) ERBB2ERBB4MMP1MMP2MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
EP-1765796-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS Pfizer Products Inc. (US) 2007-03-28 — — EP disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
WO-2006003495-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER PRODUCTS INC. (US) 2006-01-12 — — WO disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD ERBB2 2286/4885ERBB4 2879/4885ADAMTS4 4341/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD ERBB2 2776/4885ERBB4 3289/4885ADAMTS4 4338/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD ERBB2 2776/4885ERBB4 3289/4885ADAMTS4 4338/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.