Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.44 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.42 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | GPR39 | O43194 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871995 | 0.75 | NPC1 (0.50) | APPALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL10053493 | 0.74 | APP (0.54) | APPCSNK1DCSNK1G2ALDH1A3METTL3 | |
| SCHEMBL18443123 | 0.74 | APP (0.54) | APPCSNK1DCSNK1G2ALDH1A3METTL3 | |
| SCHEMBL13469261 | 0.74 | APP (0.50) | APPCSNK1DCSNK1G2ALDH1A3METTL3 | |
| SCHEMBL869867 | 0.74 | APP (0.43) | APPALDH1A3METTL3AHRALDH1A1 | |
| SCHEMBL14046264 | 0.74 | PIK3CG (0.38) | APPALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL4784975 | 0.74 | RAB9A (0.51) | APPALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL11914801 | 0.74 | PIK3CG (0.55) | APPAHRALDH1A1NPC1RAB9A | |
| SCHEMBL5773449 | 0.74 | APP (0.43) | APPALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL1733873 | 0.72 | PTGS1 (0.53) | APPCSNK1DCSNK1G2ALDH1A3METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080171740-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | US | disclosed |
| EP-1793825-A2 | CHEMCIAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006036816-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171740-A1 | Chemical Compounds | CXCR4, CCR5, CXCR3 | APP 2338/4885CSNK1D 4277/4885CSNK1G2 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.