Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 9/20 | 0.64 |
| ▸ | CTSS | P25774 | 5/20 | 0.64 |
| ▸ | CTSB | P07858 | 5/20 | 0.61 |
| ▸ | CTSL | P07711 | 1/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898712 | 0.87 | CTSK (0.73) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4898705 | 0.87 | CTSK (0.73) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4895669 | 0.87 | CTSK (0.73) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4898805 | 0.84 | CTSK (0.70) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4889472 | 0.80 | CTSK (0.77) | CTSKCTSSCTSBALDH1A1MEN1 | |
| SCHEMBL4898182 | 0.80 | CTSS (0.61) | CTSKCTSSALDH1A1MEN1KMT2A | |
| SCHEMBL4898191 | 0.80 | CTSS (0.61) | CTSKCTSSALDH1A1MEN1KMT2A | |
| SCHEMBL4898169 | 0.80 | CTSS (0.61) | CTSKCTSSALDH1A1MEN1KMT2A | |
| SCHEMBL4897335 | 0.78 | CTSK (1.00) | CTSKCTSSCTSB | |
| SCHEMBL4789866 | 0.73 | CTSK (0.70) | CTSKCTSSCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234274-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | US | claimed |
| EP-1532124-B1 | Use of nitrile derivatives as medicament. | ASTRAZENECA AB (SE) | 2006-07-19 | — | — | EP | claimed |
| US-20050245522-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | claimed |
| US-20080234274-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | US | disclosed |
| EP-1532124-B1 | Use of nitrile derivatives as medicament. | ASTRAZENECA AB (SE) | 2006-07-19 | — | — | EP | disclosed |
| US-20050245522-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234274-A1 | Novel Compounds | CTSS, CTSB, CTSF | CTSK 8/4885CTSS 1/4885CTSB 2/4885 |
| US-20050245522-A1 | Novel compounds | CTSS, CTSB, CTSF | CTSK 8/4885CTSS 1/4885CTSB 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.