Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28167462 | 0.71 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1KDM4ETDP1POLB | |
| SCHEMBL5897566 | 0.70 | PTPN1 (0.47) | ALDH1A1POLBPTPN1SMN1; SMN2KCNN4 | |
| SCHEMBL28669527 | 0.70 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1KDM4ETDP1POLB | |
| SCHEMBL7184769 | 0.70 | ALDH1A1 (0.41) | ALDH1A1KDM4ECYP2D6CYP1A2KCNN4 | |
| SCHEMBL3413596 | 0.69 | PTPN1 (0.60) | PTPN1CYP1A2 | |
| SCHEMBL15133381 | 0.68 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1KDM4ETDP1POLB | |
| Water SCHEMBL5935323 | 0.67 | PTPN1 (0.58) | PTPN1CYP1A2 | |
| Water SCHEMBL5162579 | 0.67 | PTPN1 (0.58) | PTPN1CYP1A2 | |
| Biphenyl SCHEMBL28235482 | 0.67 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1KDM4ETDP1POLB | |
| SCHEMBL4193999 | 0.67 | ALDH1A1 (0.64) | ALDH1A1L3MBTL1KDM4ETDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200679-A1 | Alpha-HYDROXY, alpha-SUBSTITUTED METHYLENEBISPHOSPHONATES AND PHOSPHONOACETATES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2008-08-21 | — | — | US | disclosed |
| EP-1097160-A4 | PREPARATION AND USE OF ALPHA-KETO BISPHOSPHONATES | UNIV SOUTHERN CALIFORNIA (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-1097160-A1 | PREPARATION AND USE OF ALPHA-KETO BISPHOSPHONATES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2001-05-09 | — | — | EP | disclosed |
| US-6147245-A | Preparation and use of α-Keto Bisphosphonates | UNIVERSITY OF SOUTHERN CALIFORNIA UNIVERSITY PARK (US) | 2000-11-14 | — | — | US | disclosed |
| WO-2000002889-A1 | PREPARATION AND USE OF α-KETO BISPHOSPHONATES | THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2000-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200679-A1 | Alpha-HYDROXY, alpha-SUBSTITUTED METHYLENEBISPHOSPHONATES AND PHOSPHONOACETATES | GRHPR, PHPT1, PHYKPL | ALDH1A1 493/4885L3MBTL1 2427/4885KDM4E 3921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.