SCHEMBL4898499

SCHEMBL4898499

Nc1ncnc2c1ncn2[C@@H]1C=C[C@H](CO)[C@@H](O)C1

nearest known ligand 0.69

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ADCY5 O95622 13/20 0.60
AHCY P23526 3/20 0.57
ADORA2B P29275 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4894877 1.00 ADCY5 (0.60) ADCY5AHCYADORA2B
SCHEMBL7588460 1.00 ADCY5 (0.60) ADCY5AHCYADORA2B
SCHEMBL5997273 0.84 ADCY5 (0.74) ADCY5AHCYADORA2B
SCHEMBL12157255 0.84 ADCY5 (0.74) ADCY5AHCYADORA2B
SCHEMBL5998483 0.84 ADCY5 (0.74) ADCY5AHCYADORA2B
SCHEMBL5997270 0.84 ADCY5 (0.74) ADCY5AHCYADORA2B
SCHEMBL111590 0.84 ADCY5 (0.74) ADCY5AHCYADORA2B
SCHEMBL30969131 0.84 ADCY5 (0.74) ADCY5AHCYADORA2B
SCHEMBL9147328 0.82 ADCY5 (0.64) ADCY5AHCY
SCHEMBL8660508 0.82 ADCY5 (0.64) ADCY5AHCY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080176813-A1 CARBOCYCLIC NUCLEOSIDES AND PROCESS FOR OBTAINING SUCH STICHTING REGA VZW (BE) 2008-07-24 US claimed
EP-1210347-B1 CARBOCYCLIC NUCLEOSIDES AND PROCESS FOR OBTAINING SUCH STICHTING REGA V Z W (BE) 2004-06-23 EP claimed
US-20080176813-A1 CARBOCYCLIC NUCLEOSIDES AND PROCESS FOR OBTAINING SUCH STICHTING REGA VZW (BE) 2008-07-24 US disclosed
EP-1244667-B1 CYCLOHEXENE NUCLEIC ACIDS LEUVEN K U RES & DEV (BE) 2006-04-05 EP disclosed
EP-1210347-B1 CARBOCYCLIC NUCLEOSIDES AND PROCESS FOR OBTAINING SUCH STICHTING REGA V Z W (BE) 2004-06-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080176813-A1 CARBOCYCLIC NUCLEOSIDES AND PROCESS FOR OBTAINING SUCH ATIC, ADORA2A, ADORA3 ADCY5 61/4885AHCY 151/4885ADORA2B 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.