Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089289 | 0.86 | ALDH1A1 (0.61) | APEX1ALDH1A1HSD17B10ATMLMNA | |
| SCHEMBL11354000 | 0.85 | ALDH1A1 (0.65) | APEX1ALDH1A1HSD17B10ATMLMNA | |
| SCHEMBL10686326 | 0.84 | ALDH1A1 (0.60) | APEX1ALDH1A1HSD17B10ATMLMNA | |
| SCHEMBL13593519 | 0.84 | LMNA (0.63) | APEX1ALDH1A1HSD17B10ATMLMNA | |
| SCHEMBL19302753 | 0.83 | KDM4E (0.55) | APEX1ALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL11113459 | 0.83 | APEX1 (0.51) | APEX1ALDH1A1HSD17B10ATMLMNA | |
| SCHEMBL28111637 | 0.81 | ALDH1A1 (0.57) | APEX1ALDH1A1HSD17B10ATMLMNA | |
| SCHEMBL17580983 | 0.81 | APEX1 (0.67) | APEX1ALDH1A1HSD17B10ATMLMNA | |
| SCHEMBL18132383 | 0.81 | LMNA (0.63) | APEX1ALDH1A1HSD17B10ATMLMNA | |
| SCHEMBL7403091 | 0.80 | LMNA (0.59) | APEX1ALDH1A1HSD17B10ATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109111415-B | Dendrobium alkaloid derivative, preparation method and medical application | 安徽中医药大学 | 2022-08-23 | — | — | CN | disclosed |
| CN-104974221-B | Dipeptide and tripeptide proteasome inhibitors and preparation method and pharmaceutical application thereof | 中国医学科学院药物研究所 | 2020-10-23 | — | — | CN | disclosed |
| CN-106831389-B | Method for producing carboxylic acid compound | 中国科学技术大学 | 2020-03-31 | — | — | CN | disclosed |
| CN-106831389-A | The preparation method of carboxylic acid compound | 中国科学技术大学 | 2017-06-13 | — | — | CN | disclosed |
| US-20160090383-A1 | ANTIBACTERIAL PHTHALIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2016-03-31 | — | — | US | disclosed |
| US-20160090383-A1 | ANTIBACTERIAL PHTHALIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2016-03-31 | — | — | US | disclosed |
| US-20160090383-A1 | ANTIBACTERIAL PHTHALIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2016-03-31 | — | — | US | disclosed |
| EP-2994466-A1 | ANTIBACTERIAL PHTHALIDE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2016-03-16 | — | — | EP | disclosed |
| CN-105164118-A | Antibacterial phthalide derivatives | ACTELION PHARMACEUTICALS LTD | 2015-12-16 | — | — | CN | disclosed |
| CN-104974221-A | Dipeptide and tripeptide proteasome inhibitors as well as preparation method and pharmaceutical application thereof | INST MATERIA MEDICA CAMS | 2015-10-14 | — | — | CN | disclosed |
| EP-0841063-A1 | KETONE DERIVATIVES AND MEDICINAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1998-05-13 | — | — | EP | disclosed |
| EP-0737189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-10-16 | — | — | EP | disclosed |
| WO-1995018118-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1995-07-06 | — | — | WO | disclosed |
| US-5430056-A | Treatment of disorders of central nervous, cardiovascular and endocrine systems | DISCOVERY THERAPEUTICS, INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5358971-A | For disorders of CNS, cardiovascular and endocrine systems, inducing anorexia and weight loss | WHITBY RESEARCH, INC. (US) | 1994-10-25 | — | — | US | disclosed |
| US-5274003-A | A 3-naphthyloxy- or -thioaklyleneamino-8-hydroxytetralin derivative | WHITBY RESEARCH, INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0463119-A4 | SUBSTITUTED 2-AMINOTETRALINS | — | 1992-01-22 | — | — | EP | disclosed |
| EP-0463119-A1 | use of SUBSTITUTED 2-AMINOTETRALINS for the preparation of a medicament for inducing anorexia or weight loss. | Whitby Research Incorporated (US) | 1992-01-02 | — | — | EP | disclosed |
| WO-1991000727-A1 | SUBSTITUTED 2-AMINOTETRALINS | WHITBY RESEARCH, INC. (US) | 1991-01-24 | — | — | WO | disclosed |
| EP-0350163-A2 | Renin inhibitory peptides | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160090383-A1 | ANTIBACTERIAL PHTHALIDE DERIVATIVES | MRPL21, MAPRE1, HDAC6 | APEX1 2726/4885ALDH1A1 771/4885HSD17B10 1715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.