Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 8/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.35 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897242 | 0.93 | ADORA2B (0.42) | ADORA2BADORA1ADORA2ATDP1ALDH1A1 | |
| SCHEMBL4866634 | 0.88 | ADORA2B (0.45) | ADORA2BADORA1ADORA2AALDH1A1SCD5 | |
| SCHEMBL4904896 | 0.88 | NPBWR1 (0.47) | ADORA2BADORA1ADORA2ATDP1NPBWR1 | |
| SCHEMBL4895305 | 0.88 | ADORA2A (0.40) | ADORA2BADORA1ADORA2A | |
| SCHEMBL4916169 | 0.88 | ADORA2B (0.48) | ADORA2BADORA1ADORA2ATDP1ALDH1A1 | |
| SCHEMBL4908302 | 0.87 | ADORA2B (0.45) | ADORA2BADORA1ADORA2ATDP1ALDH1A1 | |
| SCHEMBL4917944 | 0.87 | ADORA2B (0.50) | ADORA2BADORA1ADORA2ATDP1ALDH1A1 | |
| SCHEMBL4891672 | 0.86 | ADORA2B (0.53) | ADORA2BADORA1ADORA2ATDP1ALDH1A1 | |
| SCHEMBL4893609 | 0.85 | ADORA2B (0.49) | ADORA2BADORA1ADORA2ATDP1ALDH1A1 | |
| SCHEMBL4763420 | 0.85 | ADORA2A (0.39) | ADORA2BADORA1ADORA2ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449473-B2 | Substituted pyrrolo[3,2-d]pyrimidin-2,4-diones as A2b adenosine receptor antagonists | CV THERAPEUTICS, INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-20050119287-A1 | A2B adenosine receptor antagonists | GILEAD PALO ALTO, INC. | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119287-A1 | A2B adenosine receptor antagonists | ADORA2B, ADORA2A, ADORA3 | ADORA2B 1/4885ADORA1 4/4885ADORA2A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.