SCHEMBL490074

SCHEMBL490074

C=CC(=O)NC(CC(N)=O)C(N)=O

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.43
ECE1 P42892 3/20 0.42
ALDH1A1 P00352 3/20 0.37
MAPK1 P28482 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
FGFR4 P22455 1/20 0.33
CYP2C19 P33261 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ITGB2 P05107 1/20 0.32
ICAM1 P05362 1/20 0.32
ITGAL P20701 1/20 0.32
CA2 P00918 3/20 0.30
CA1 P00915 2/20 0.30
RAB9A P51151 1/20 0.30
SCN9A Q15858 1/20 0.30
CA12 O43570 1/20 0.30
CA9 Q16790 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL490075 1.00 TSHR (0.43) TSHRECE1ALDH1A1MAPK1TDP1
SCHEMBL8186324 0.86 ECE1 (0.46) TSHRECE1ALDH1A1MAPK1TDP1
SCHEMBL3437894 0.86 ECE1 (0.46) TSHRECE1ALDH1A1MAPK1TDP1
SCHEMBL8376937 0.82 TSHR (0.45) TSHRALDH1A1MAPK1TDP1FGFR4
SCHEMBL8376938 0.82 TSHR (0.45) TSHRALDH1A1MAPK1TDP1FGFR4
SCHEMBL490611 0.81 TSHR (0.41) TSHRALDH1A1MAPK1TDP1FGFR4
SCHEMBL490612 0.81 TSHR (0.41) TSHRALDH1A1MAPK1TDP1FGFR4
SCHEMBL30414359 0.80 TSHR (0.43) TSHRALDH1A1MAPK1TDP1FGFR4
SCHEMBL8379983 0.80 TSHR (0.43) TSHRALDH1A1MAPK1TDP1FGFR4
SCHEMBL8379982 0.80 TSHR (0.43) TSHRALDH1A1MAPK1TDP1FGFR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210156849-A1 ANALYTICAL METHOD, REAGENT KIT AND ANALYTIC DEVICE CANON MEDICAL SYSTEMS CORPORATION (JP) 2021-05-27 US disclosed
WO-2020027234-A1 ANALYSIS METHOD, REAGENT KIT, AND ANALYZING DEVICE キヤノンメディカルシステムズ株式会社 2020-02-06 WO disclosed
US-20190170758-A1 METHOD OF DETECTION WITH A FLUORESCENT LABELING PARTICLE FURUKAWA ELECTRIC CO., LTD. (JP) 2019-06-06 US disclosed
US-10203326-B2 Method of detecting target substance FURUKAWA ELECTRIC CO., LTD. (JP) 2019-02-12 US disclosed
US-20190011442-A1 METHOD FOR DETECTING SUBSTANCE OF INTEREST, METHOD FOR QUANTIFYING SUBSTANCE OF INTEREST, KIT, AND METHOD FOR PREPARING REAGENT FURUKAWA ELECTRIC CO., LTD. (JP) 2019-01-10 US disclosed
US-20180348228-A1 Method of Determining Quantity of Objects to be Detected in Specimen ORTHO CLINICAL DIAGNOSTICS KK (JP) 2018-12-06 US disclosed
EP-3054283-B1 METHOD FOR DETECTING TARGET SUBSTANCE FURUKAWA ELECTRIC CO LTD (JP) 2018-12-05 EP disclosed
US-20160291003-A1 METHOD OF DETECTING TARGET SUBSTANCE FURUKAWA ELECTRIC CO., LTD. (JP) 2016-10-06 US disclosed
EP-3054297-A1 FLUORESCENCE-LABELED PARTICLE Furukawa Electric Co. Ltd. (JP) 2016-08-10 EP disclosed
EP-3054283-A1 METHOD FOR DETECTING TARGET SUBSTANCE Furukawa Electric Co. Ltd. (JP) 2016-08-10 EP disclosed
US-8105493-B2 Aggregation and dispersion methods of magnetic particles, separation and detection methods using the same and detection kit JNC CORPORATION (JP) 2012-01-31 US disclosed
US-20110233453-A1 METHOD OF STORING THERMORESPONSIVE POLYMER IN STATE OF AQUEOUS SOLUTION CHISSO CORPORATION (JP) 2011-09-29 US disclosed
US-7976728-B2 Aqueous solution of polymer having upper critical solution temperature, aqueous dispersion of particle modified with the polymer and method of storing the same JNC CORPORATION (JP) 2011-07-12 US disclosed
EP-2009044-B1 Method of storing an aqueous dispersion of particle modified with a polymer having upper critical solution temperature JNC CORP (JP) 2011-06-15 EP disclosed
US-20090001321-A1 AQUEOUS SOLUTION OF POLYMER HAVING UPPER CRITICAL SOLUTION TEMPERATURE, AQUEOUS DISPERSION OF PARTICLE MODIFIED WITH THE POLYMER AND METHOD OF STORING THE SAME CHISSO CORPORATION (JP) 2009-01-01 US disclosed
US-20090001025-A1 AGGREGATION AND DISPERSION METHODS OF MAGNETIC PARTICLES, SEPARATION AND DETECTION METHODS USING THE SAME AND DETECTION KIT CHISSO CORPORATION (JP) 2009-01-01 US disclosed
EP-2009044-A1 Aqueous solution of polymer having upper critical solution temperature, aqueous dispersion of particle modified with the polymer and method of storing the same Chisso Corporation (JP) 2008-12-31 EP disclosed
EP-2009442-A2 Aggregation and dispersion methods of magnetic particles, separation and detection methods using the same and detection kit Chisso Corporation (JP) 2008-12-31 EP disclosed
US-5883211-A Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis ACLARA BIOSCIENCES, INC. (US) 1999-03-16 US disclosed
WO-1997040078-A1 THERMOREVERSIBLE HYDROGELS COMPRISING NON-CROSSLINKED COPOLYMERS AND THEIR USE IN ELECTROPHORESIS SOANE BIOSCIENCES (US) 1997-10-30 WO disclosed