SCHEMBL490075

SCHEMBL490075

C=CC(=O)N[C@@H](CC(N)=O)C(N)=O

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.43
ECE1 P42892 3/20 0.42
ALDH1A1 P00352 3/20 0.37
MAPK1 P28482 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
FGFR4 P22455 1/20 0.33
CYP2C19 P33261 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ITGB2 P05107 1/20 0.32
ICAM1 P05362 1/20 0.32
ITGAL P20701 1/20 0.32
CA2 P00918 3/20 0.30
CA1 P00915 2/20 0.30
RAB9A P51151 1/20 0.30
SCN9A Q15858 1/20 0.30
CA12 O43570 1/20 0.30
CA9 Q16790 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL490074 1.00 TSHR (0.43) TSHRECE1ALDH1A1MAPK1TDP1
SCHEMBL8186324 0.86 ECE1 (0.46) TSHRECE1ALDH1A1MAPK1TDP1
SCHEMBL3437894 0.86 ECE1 (0.46) TSHRECE1ALDH1A1MAPK1TDP1
SCHEMBL8376937 0.82 TSHR (0.45) TSHRALDH1A1MAPK1TDP1FGFR4
SCHEMBL8376938 0.82 TSHR (0.45) TSHRALDH1A1MAPK1TDP1FGFR4
SCHEMBL490611 0.81 TSHR (0.41) TSHRALDH1A1MAPK1TDP1FGFR4
SCHEMBL490612 0.81 TSHR (0.41) TSHRALDH1A1MAPK1TDP1FGFR4
SCHEMBL30414359 0.80 TSHR (0.43) TSHRALDH1A1MAPK1TDP1FGFR4
SCHEMBL8379983 0.80 TSHR (0.43) TSHRALDH1A1MAPK1TDP1FGFR4
SCHEMBL8379982 0.80 TSHR (0.43) TSHRALDH1A1MAPK1TDP1FGFR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12613069-B2 Method for forming temperature-responsive hydrophilic-hydrophobic conversion surface, and temperature-responsive hydrophilic-hydrophobic conversion surface and heat exchanger, using same IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) (KR) 2026-04-28 US claimed
EP-4719345-A1 THERMOSTABLE COMPOSITIONS COMPRISING MRNA LIPID NANOPARTICLES Sanofi Pasteur Inc. (US) 2026-04-08 EP claimed
US-20250084285-A1 THERMO-SWITCHABLE PRESSURE-SENSITIVE ADHESIVES NORTHEASTERN UNIVERSITY 2025-03-13 US claimed
EP-4506464-A1 CRISPR-COACERVATE SYSTEM ETH Zurich (CH) 2025-02-12 EP claimed
WO-2024246358-A1 THERMOSTABLE COMPOSITIONS COMPRISING MRNA LIPID NANOPARTICLES SANOFI (FR) 2024-12-05 WO claimed
EP-3640305-B1 USE OF A POLYMER WITH UCST IN A COATING COMPOSITION, IN PARTICULAR FOR PAINT, TO IMPROVE DRYING CROMOLOGY (FR) 2024-12-04 EP claimed
US-20240295370-A1 METHOD FOR FORMING TEMPERATURE-RESPONSIVE HYDROPHILIC-HYDROPHOBIC CONVERSION SURFACE, AND TEMPERATURE-RESPONSIVE HYDROPHILIC-HYDROPHOBIC CONVERSION SURFACE AND HEAT EXCHANGER, USING SAME IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) (KR) 2024-09-05 US claimed
US-20230285893-A1 WATER SORBING MATERIALS AND RELATED SYSTEMS AND METHODS UNIV KHALIFA SCIENCE & TECHNOLOGY (AE) 2023-09-14 US claimed
WO-2022240203-A1 METHOD FOR FORMING TEMPERATURE-RESPONSIVE HYDROPHILIC-HYDROPHOBIC CONVERSION SURFACE, AND TEMPERATURE-RESPONSIVE HYDROPHILIC-HYDROPHOBIC CONVERSION SURFACE AND HEAT EXCHANGER, USING SAME 한양대학교 산학협력단 2022-11-17 WO claimed
WO-2022049480-A1 WATER SORBING MATERIALS AND RELATED SYSTEMS AND METHODS Khalifa University of Science and Technology (AE) 2022-03-10 WO claimed
US-20160280572-A1 POLYMERS FOR FLOCCULATION, DEWATERING AND CONSOLIDATION OF OIL SANDS FLUID FINE TAILINGS, MINE TAILINGS AND SOLID PARTICULATE SUSPENSIONS THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2016-09-29 US claimed
US-8105493-B2 Aggregation and dispersion methods of magnetic particles, separation and detection methods using the same and detection kit JNC CORPORATION (JP) 2012-01-31 US claimed
US-8105503-B2 Method of storing thermoresponsive polymer in state of aqueous solution CHISSO CORPORATION (JP) 2012-01-31 US claimed
US-20110233453-A1 METHOD OF STORING THERMORESPONSIVE POLYMER IN STATE OF AQUEOUS SOLUTION CHISSO CORPORATION (JP) 2011-09-29 US claimed
US-7976728-B2 Aqueous solution of polymer having upper critical solution temperature, aqueous dispersion of particle modified with the polymer and method of storing the same JNC CORPORATION (JP) 2011-07-12 US claimed
EP-2009044-B1 Method of storing an aqueous dispersion of particle modified with a polymer having upper critical solution temperature JNC CORP (JP) 2011-06-15 EP claimed
US-20090001321-A1 AQUEOUS SOLUTION OF POLYMER HAVING UPPER CRITICAL SOLUTION TEMPERATURE, AQUEOUS DISPERSION OF PARTICLE MODIFIED WITH THE POLYMER AND METHOD OF STORING THE SAME CHISSO CORPORATION (JP) 2009-01-01 US claimed
US-20090001025-A1 AGGREGATION AND DISPERSION METHODS OF MAGNETIC PARTICLES, SEPARATION AND DETECTION METHODS USING THE SAME AND DETECTION KIT CHISSO CORPORATION (JP) 2009-01-01 US claimed
EP-2009044-A1 Aqueous solution of polymer having upper critical solution temperature, aqueous dispersion of particle modified with the polymer and method of storing the same Chisso Corporation (JP) 2008-12-31 EP claimed
EP-2009442-A2 Aggregation and dispersion methods of magnetic particles, separation and detection methods using the same and detection kit Chisso Corporation (JP) 2008-12-31 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12613069-B2 Method for forming temperature-responsive hydrophilic-hydrophobic conversion surface, and temperature-responsive hydrophilic-hydrophobic conversion surface and heat exchanger, using same HSF1, SLC9A2, SLC7A1 TSHR 191/4885ECE1 4481/4885ALDH1A1 3380/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.