Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 3/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5832076 | 0.89 | MMP13 (0.45) | HSP90AA1HSP90B1MMP13CYP11B1CYP11B2 | |
| SCHEMBL4904745 | 0.84 | EGLN1 (0.53) | HSP90AA1HSP90B1MMP13CYP11B1CYP11B2 | |
| SCHEMBL20591088 | 0.80 | CYP11B2 (0.48) | HSP90AA1HSP90B1CYP11B1CYP11B2LMNA | |
| SCHEMBL4909246 | 0.80 | EGLN1 (0.44) | MMP13LMNAHSD17B13 | |
| SCHEMBL28430515 | 0.78 | PKM (0.57) | HSP90AA1HSP90B1CYP11B1CYP11B2LMNA | |
| SCHEMBL1684151 | 0.77 | MMP13 (0.36) | HSP90AA1HSP90B1MMP13MAPK14HSD17B13 | |
| SCHEMBL2945788 | 0.74 | MMP13 (0.48) | HSP90AA1HSP90B1MMP13CYP11B1CYP11B2 | |
| SCHEMBL2946785 | 0.74 | CYP11B1 (0.46) | HSP90AA1HSP90B1MMP13CYP11B1CYP11B2 | |
| SCHEMBL6296213 | 0.72 | MMP13 (0.66) | MMP13LMNA | |
| SCHEMBL27244146 | 0.72 | CYP11B2 (0.45) | MMP13CYP11B1CYP11B2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221154-A1 | HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE | PFIZER INC | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221154-A1 | HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE | TYMP, IMPDH1, POLB | HSP90AA1 1785/4885HSP90B1 2101/4885MMP13 1047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.