Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903920 | 0.84 | HSP90AA1 (0.47) | CYP11B1CYP11B2HSP90AA1HSP90B1KDM4E | |
| SCHEMBL4903870 | 0.84 | CYP2C19 (0.44) | EGLN1ALDH1A1MAPK14MAPT | |
| SCHEMBL20591088 | 0.79 | CYP11B2 (0.48) | YTHDC1CYP11B1CYP11B2HSP90AA1HSP90B1 | |
| SCHEMBL28430515 | 0.77 | PKM (0.57) | YTHDC1CYP11B1CYP11B2HSP90AA1HSP90B1 | |
| SCHEMBL5832076 | 0.74 | MMP13 (0.45) | EGLN1CYP11B1CYP11B2HSP90AA1HSP90B1 | |
| SCHEMBL2945788 | 0.73 | MMP13 (0.48) | CYP11B1CYP11B2HSP90AA1HSP90B1ALDH1A1 | |
| SCHEMBL2946785 | 0.73 | CYP11B1 (0.46) | CYP11B1CYP11B2HSP90AA1HSP90B1ALDH1A1 | |
| SCHEMBL1082082 | 0.71 | EGLN3 (0.52) | EGLN1YTHDC1HSP90AA1HSP90B1ALDH1A1 | |
| SCHEMBL22533905 | 0.70 | EGLN1 (0.51) | EGLN1YTHDC1PKMTSHR | |
| SCHEMBL29424721 | 0.70 | EGLN1 (0.51) | EGLN1YTHDC1PKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221154-A1 | HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE | PFIZER INC | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221154-A1 | HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE | TYMP, IMPDH1, POLB | EGLN1 311/4885YTHDC1 4422/4885CYP11B1 1112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.