Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 16/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
| ▸ | EIF4E | P06730 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4908938 | 0.92 | SCN10A (0.44) | TRPM8SCN10AHCRTR2SHMT2 | |
| SCHEMBL4895709 | 0.88 | TP53 (0.43) | TRPM8EIF4E | |
| SCHEMBL4899849 | 0.87 | LMNA (0.46) | TRPM8EIF4E | |
| SCHEMBL4906638 | 0.87 | ALDH1A1 (0.44) | EIF4E | |
| SCHEMBL4895921 | 0.85 | LMNA (0.40) | TRPM8HCRTR2 | |
| SCHEMBL4906585 | 0.85 | LMNA (0.43) | EIF4E | |
| SCHEMBL4903605 | 0.85 | TRPM8 (0.47) | TRPM8 | |
| SCHEMBL4906642 | 0.83 | HCRTR2 (0.54) | TRPM8HCRTR2 | |
| SCHEMBL4902609 | 0.82 | TP53 (0.43) | — | |
| SCHEMBL4903288 | 0.81 | LMNA (0.47) | EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | TRPM8 4317/4885SCN10A 3411/4885EIF4E 3036/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | TRPM8 4317/4885SCN10A 3411/4885EIF4E 3036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.