Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781992 | 0.85 | RXRB (0.46) | PLK1GAAKDM4EL3MBTL1LMNA | |
| SCHEMBL4782119 | 0.84 | L3MBTL1 (0.43) | PLK1GAAKDM4EMAPTL3MBTL1 | |
| SCHEMBL25301615 | 0.83 | PLK1 (0.48) | PLK1GAAKDM4EMAPTATAD2 | |
| SCHEMBL30497195 | 0.83 | PLK1 (0.48) | PLK1GAAKDM4EMAPTATAD2 | |
| SCHEMBL25262781 | 0.81 | ATAD2 (0.46) | PLK1GAAKDM4EMAPTATAD2 | |
| SCHEMBL1300650 | 0.77 | L3MBTL1 (0.64) | PLK1GAAMAPTL3MBTL1LMNA | |
| SCHEMBL13938063 | 0.76 | PLK1 (0.68) | PLK1GAAKDM4EMAPTL3MBTL1 | |
| SCHEMBL2033863 | 0.74 | CA1 (0.54) | GAAKDM4EL3MBTL1LMNAHPGD | |
| SCHEMBL546298 | 0.74 | CA1 (0.54) | GAAKDM4EMAPTL3MBTL1LMNA | |
| SCHEMBL3350685 | 0.74 | KIFC1 (0.40) | PLK1KDM4EMAPTATAD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |