Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.37 |
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL10902441 | 0.88 | ALDH1A1 (0.47) | ALDH1A1CHRNA7CHRM2ACHECHRNB4 | |
| SCHEMBL13109192 | 0.86 | ALDH1A1 (0.50) | ALDH1A1CHRNA7PSMD14HSP90AA1MMP2 | |
| Hydrochloric Acid SCHEMBL28453309 | 0.83 | CHRM2 (0.38) | ALDH1A1CHRNA7CHRM2ACHEBCHE | |
| Hydrochloric Acid SCHEMBL475899 | 0.83 | ALDH1A1 (0.42) | ALDH1A1CHRNA7PSMD14HSP90AA1MMP2 | |
| Hydrochloric Acid SCHEMBL11499887 | 0.83 | CHRM2 (0.38) | ALDH1A1CHRNA7CHRM2ACHEBCHE | |
| Hydrochloric Acid SCHEMBL11050413 | 0.82 | ALDH1A1 (0.41) | ALDH1A1CHRNA7CHRM2ACHECHRNB2 | |
| SCHEMBL4936757 | 0.82 | ALDH1A1 (0.46) | ALDH1A1CHRNA7PSMD14HSP90AA1MMP2 | |
| Hydrochloric Acid SCHEMBL4897127 | 0.82 | ACHE (0.40) | ALDH1A1CHRNA7CHRM2ACHEBCHE | |
| Hydrochloric Acid SCHEMBL563027 | 0.81 | ALDH1A1 (0.41) | ALDH1A1CHRNA7PSMD14HSP90AA1MMP2 | |
| Hydrochloric Acid SCHEMBL475648 | 0.81 | ALDH1A1 (0.50) | ALDH1A1CHRNA7ACHEBCHEPSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080003288-A1 | Responsive microgel and methods related thereto | SUPRATEK PHARMA INC. (CA) | 2008-01-03 | — | — | US | disclosed |
| US-7204997-B2 | Responsive microgel and methods related thereto | SUPRATEK PHARMA INC. (CA) | 2007-04-17 | — | — | US | disclosed |
| EP-1478403-A1 | RESPONSIVE MICROGEL AND METHODS RELATED THERETO | SUPRATEK PHARMA, INC. (CA) | 2004-11-24 | — | — | EP | disclosed |
| US-20030152623-A1 | Responsive microgel and methods related thereto | SUPRATEK PHARMA INC. (CA) | 2003-08-14 | — | — | US | disclosed |
| WO-2003063909-A1 | RESPONSIVE MICROGEL AND METHODS RELATED THERETO | SUPRATEK PHARMA INC. (US) | 2003-08-07 | — | — | WO | disclosed |