Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LHCGR | P22888 | 8/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
| ▸ | FSHR | P23945 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4908873 | 0.90 | LHCGR (0.55) | LHCGRTSHRBRAFFSHRMEN1 | |
| SCHEMBL4899393 | 0.86 | BRAF (0.58) | LHCGRBRAFNPC1RAB9AMEN1 | |
| SCHEMBL4909137 | 0.85 | LHCGR (0.54) | LHCGRTSHRFSHRNPC1RAB9A | |
| SCHEMBL5136975 | 0.85 | LHCGR (0.51) | LHCGRTSHRBRAFFSHRNPC1 | |
| SCHEMBL17467741 | 0.80 | LHCGR (0.82) | LHCGRTSHRBRAFFSHRNPC1 | |
| SCHEMBL14281547 | 0.78 | IKBKB (0.46) | NPC1RAB9AMEN1KMT2ACHRM4 | |
| SCHEMBL14466565 | 0.76 | BRAF (0.70) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4313210 | 0.76 | LHCGR (1.00) | LHCGRTSHRBRAFFSHRNPC1 | |
| SCHEMBL6215212 | 0.73 | MAPT (0.55) | LHCGRTSHRBRAFNPC1RAB9A | |
| SCHEMBL6927090 | 0.73 | LHCGR (0.64) | LHCGRTSHRBRAFFSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | MCKENNA JEFFREY M | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | PDE4A, PDE4B, BRAF | LHCGR 2693/4885TSHR 1074/4885BRAF 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.