Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 4/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CCR7 | P32248 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4899189 | 0.99 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4904071 | 0.88 | CYP1A2 (0.51) | CYP3A4KIF11NR3C2CYP1A2CTSL | |
| SCHEMBL4909219 | 0.87 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Hydrochloric Acid SCHEMBL4908124 | 0.86 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4904069 | 0.86 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14258726 | 0.81 | KIF11 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14258733 | 0.81 | SCN9A (0.43) | CYP2D6CYP3A4NR3C2CYP1A2CYP2C19 | |
| SCHEMBL14258727 | 0.80 | SCN9A (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14258737 | 0.80 | SCN9A (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Hydrochloric Acid SCHEMBL4904250 | 0.80 | SCN9A (0.42) | CYP2D6CYP3A4NR3C2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058391-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-03-06 | — | — | US | claimed |
| US-20080058391-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-03-06 | — | — | US | disclosed |
| US-20080058391-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-03-06 | — | — | US | disclosed |
| US-20080058391-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-03-06 | — | — | US | disclosed |
| WO-2008017691-A1 | PYRIDINE DERIVATIVES AS SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058391-A1 | NOVEL COMPOUNDS | HCN3, KCNN3, HCN4 | PSEN1 2084/4885PSEN2 3329/4885APH1B 4039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.