Sugi Predict

Sugi Predict / Compounds / SCHEMBL4906910

SCHEMBL4906910

SCHEMBL4906910

CCc1ccc(S(=O)(=O)NCCOc2ccc(C(C)(C)C)cc2)cc1C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 6/20 0.47
▸ MEN1 O00255 5/20 0.47
▸ HTT P42858 2/20 0.47
▸ NPSR1 Q6W5P4 2/20 0.47
▸ ALDH1A1 P00352 5/20 0.46
▸ TDP1 Q9NUW8 1/20 0.45
▸ SMN1; SMN2 Q16637 2/20 0.44
▸ LMNA P02545 1/20 0.44
▸ NPC1 O15118 1/20 0.44
▸ POLB P06746 1/20 0.44
▸ CASP3 P42574 1/20 0.44
▸ RAB9A P51151 1/20 0.44
▸ SENP7 Q9BQF6 1/20 0.44
▸ KDM4E B2RXH2 2/20 0.43
▸ MITF O75030 1/20 0.43
▸ GAA P10253 1/20 0.43
▸ GPR35 Q9HC97 1/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.43
▸ TP53 P04637 1/20 0.43
▸ CA12 O43570 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4906225 0.91 NPSR1 (0.46) KMT2AMEN1HTTNPSR1ALDH1A1
SCHEMBL4906098 0.88 LMNA (0.54) KMT2AMEN1HTTNPSR1ALDH1A1
SCHEMBL4908583 0.83 HTT (0.48) KMT2AMEN1HTTNPSR1ALDH1A1
SCHEMBL4902606 0.82 TDP1 (0.51) KMT2AMEN1HTTNPSR1ALDH1A1
SCHEMBL4900950 0.77 ADAMTS4 (0.49) KMT2AMEN1
SCHEMBL4904407 0.76 SMN1; SMN2 (0.48) KMT2AMEN1HTTNPSR1ALDH1A1
SCHEMBL4903155 0.76 AKR1C3 (0.48) KMT2AHTTALDH1A1TDP1SMN1; SMN2
SCHEMBL4899812 0.75 PPARG (0.43) KMT2AMEN1HTTALDH1A1SMN1; SMN2
SCHEMBL4906026 0.74 ALDH1A1 (0.49) KMT2AMEN1HTTALDH1A1LMNA
SCHEMBL4909044 0.74 AKR1C3 (0.46) KMT2AALDH1A1TDP1SMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD KMT2A 3602/4885MEN1 4859/4885HTT 711/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD KMT2A 3530/4885MEN1 4855/4885HTT 696/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD KMT2A 3530/4885MEN1 4855/4885HTT 696/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.