Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | SGMS1 | Q86VZ5 | 5/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4905595 | 0.92 | ALDH1A1 (0.45) | AKR1C3TBXA2RTBXAS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4908882 | 0.90 | LMNA (0.51) | AKR1C3TBXA2RTBXAS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4894377 | 0.85 | TBXA2R (0.45) | AKR1C3TBXA2RTBXAS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4900950 | 0.84 | ADAMTS4 (0.49) | AKR1C3TBXA2RTBXAS1KMT2A | |
| SCHEMBL4902429 | 0.84 | ALDH1A1 (0.46) | AKR1C3TBXA2RTBXAS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4899868 | 0.83 | AKR1C3 (0.48) | AKR1C3TBXA2RTBXAS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4907097 | 0.83 | ALDH1A1 (0.54) | AKR1C3TBXA2RTBXAS1ALDH1A1SGMS1 | |
| SCHEMBL4903155 | 0.83 | AKR1C3 (0.48) | AKR1C3TBXA2RTBXAS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4906061 | 0.82 | MMP2 (0.53) | AKR1C3TBXA2RTBXAS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4898067 | 0.81 | ALDH1A1 (0.57) | AKR1C3ALDH1A1SMN1; SMN2SGMS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | AKR1C3 1645/4885TBXA2R 330/4885TBXAS1 271/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | AKR1C3 1645/4885TBXA2R 330/4885TBXAS1 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.