Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 5/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.49 |
| ▸ | RELA | Q04206 | 5/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906932 | 1.00 | NFKB1 (0.49) | NFKB1NFKB2RELAEPHX2BTK | |
| SCHEMBL18045101 | 0.87 | NFKB1 (0.48) | NFKB1NFKB2RELAEPHX2BTK | |
| SCHEMBL18045102 | 0.87 | NFKB1 (0.48) | NFKB1NFKB2RELAEPHX2BTK | |
| SCHEMBL9621965 | 0.82 | NFKB1 (0.44) | NFKB1NFKB2RELAEPHX2GAA | |
| SCHEMBL4910405 | 0.82 | NFKB1 (0.44) | NFKB1NFKB2RELAEPHX2GAA | |
| SCHEMBL27712551 | 0.74 | MAPK1 (0.36) | NFKB1NFKB2RELA | |
| SCHEMBL9622035 | 0.71 | NFKB1 (0.49) | NFKB1NFKB2RELAEPHX2BTK | |
| SCHEMBL27476940 | 0.70 | NFKB1 (0.59) | NFKB1NFKB2RELAEPHX2BTK | |
| SCHEMBL23142325 | 0.70 | NFKB1 (0.48) | NFKB1NFKB2RELAEPHX2BTK | |
| SCHEMBL11428484 | 0.70 | NFKB1 (0.58) | NFKB1NFKB2RELAEPHX2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10800753-B2 | Tetrahydrothiophene-based GABA aminotransferase inactivators and analogs thereof for treating neurological disorders | NORTHWESTERN UNIVERSITY (US) | 2020-10-13 | — | — | US | disclosed |
| US-20190256489-A1 | Tetrahydrothiophene-based GABA Aminotransferase Inactivators and Analogs Thereof for Treating Neurological Disorders | NORTHWESTERN UNIVERSITY (US) | 2019-08-22 | — | — | US | disclosed |
| US-10189807-B2 | Tetrahydrothiophene-based GABA aminotransferase inactivators | NORTHWESTERN UNIVERSITY (US) | 2019-01-29 | — | — | US | disclosed |
| US-20180051001-A1 | Tetrahydrothiophene-based GABA Aminotransferase Inactivators | NORTHWESTERN UNIVERSITY (US) | 2018-02-22 | — | — | US | disclosed |
| US-9856231-B2 | Tetrahydrothiophene-based GABA aminotransferase inactivators | NORTHWESTERN UNIVERSITY (US) | 2018-01-02 | — | — | US | disclosed |
| WO-2016145082-A1 | TETRAHYDROTHIOPHENE-BASED GABA AMINOTRANSFERASE INACTIVATORS | NORTHWESTERN UNIVERSITY (US) | 2016-09-15 | — | — | WO | disclosed |
| US-20160264544-A1 | Tetrahydrothiophene-based GABA Aminotransferase Inactivators | NORTHWESTERN UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-9073966-B2 | Inhibition of sweat malodor | FIRMENICH SA (CH) | 2015-07-07 | — | — | US | disclosed |
| US-20120244098-A1 | INHIBITION OF SWEAT MALODOR | FIRMENICH SA (CH) | 2012-09-27 | — | — | US | disclosed |
| EP-1846436-B1 | INHIBITION OF SWEAT MALODOUR | FIRMENICH & CIE (CH) | 2012-09-12 | — | — | EP | disclosed |
| US-8206692-B2 | Inhibition of sweat malodor | FIRMENICH SA (CH) | 2012-06-26 | — | — | US | disclosed |
| US-20080025935-A1 | INHIBITION OF SWEAT MALODOR | FIRMENICH SA (CH) | 2008-01-31 | — | — | US | disclosed |
| EP-0145875-B1 | GAMMA-AMINOBUTYRIC ACID TRANSAMINASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-02-19 | — | — | EP | disclosed |
| EP-0145875-A2 | Gamma-aminobutyric acid transaminase inhibitors and processes for their preparation | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-06-26 | — | — | EP | disclosed |
| US-4520028-A | ANTIEPILEPTIC AGENTS; NERVOUS SYSTEM DISORDERS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190256489-A1 | Tetrahydrothiophene-based GABA Aminotransferase Inactivators and Analogs Thereof for Treating Neurological Disorders | ABAT, TPMT, TST | NFKB1 4712/4885NFKB2 4639/4885RELA 3913/4885 |
| US-20120244098-A1 | INHIBITION OF SWEAT MALODOR | SQOR, MAL2, TST | NFKB1 3041/4885NFKB2 2595/4885RELA 2691/4885 |
| US-20160264544-A1 | Tetrahydrothiophene-based GABA Aminotransferase Inactivators | ABAT, TST, DLAT | NFKB1 4508/4885NFKB2 4463/4885RELA 2920/4885 |
| US-10189807-B2 | Tetrahydrothiophene-based GABA aminotransferase inactivators | ABAT, TST, DLAT | NFKB1 4508/4885NFKB2 4463/4885RELA 2920/4885 |
| US-20180051001-A1 | Tetrahydrothiophene-based GABA Aminotransferase Inactivators | ABAT, TST, DLAT | NFKB1 4508/4885NFKB2 4463/4885RELA 2920/4885 |
| US-20080025935-A1 | INHIBITION OF SWEAT MALODOR | MAL2, SQOR, TST | NFKB1 3174/4885NFKB2 2738/4885RELA 2659/4885 |
| US-10800753-B2 | Tetrahydrothiophene-based GABA aminotransferase inactivators and analogs thereof for treating neurological disorders | ABAT, TPMT, TST | NFKB1 4712/4885NFKB2 4639/4885RELA 3913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.