SCHEMBL490726

SCHEMBL490726

COc1ccc(CCC(=O)O)cc1O

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.71
CYP19A1 P11511 1/20 0.67
CYP3A4 P08684 2/20 0.63
TSHR P16473 2/20 0.63
NFKB1 P19838 2/20 0.63
CYP1A2 P05177 1/20 0.63
MEN1 O00255 1/20 0.61
LMNA P02545 1/20 0.61
APEX1 P27695 1/20 0.61
KMT2A Q03164 1/20 0.61
TUBB4A P04350 3/20 0.59
TUBB P07437 3/20 0.59
TUBA3C P0DPH7 3/20 0.59
TUBA1B P68363 3/20 0.59
TUBA4A P68366 3/20 0.59
TUBB4B P68371 3/20 0.59
TUBB3 Q13509 3/20 0.59
TUBB2A Q13885 3/20 0.59
TUBB8 Q3ZCM7 3/20 0.59
TUBA3E Q6PEY2 3/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31337638 1.00 GAA (0.71) GAACYP19A1CYP3A4TSHRNFKB1
SCHEMBL7410835 0.89 GAA (0.65) GAACYP19A1CYP3A4TSHRNFKB1
SCHEMBL9519732 0.87 CYP19A1 (0.67) GAACYP19A1CYP3A4TSHRNFKB1
Dihydroferulic Acid SCHEMBL29383405 0.87 ALOX5 (0.74) GAACYP3A4TSHRNFKB1CYP1A2
Dihydroferulic Acid SCHEMBL347918 0.87 ALOX5 (0.74) GAACYP3A4TSHRNFKB1CYP1A2
Dihydroferulic Acid SCHEMBL30210940 0.87 ALOX5 (0.74) GAACYP3A4TSHRNFKB1CYP1A2
SCHEMBL347209 0.86 FFAR4 (0.61) MEN1KMT2AALOX5OR51E2FFAR1
SCHEMBL6339281 0.85 ALOX5 (0.77) GAACYP19A1CYP3A4TSHRNFKB1
SCHEMBL28287006 0.85 CYP19A1 (0.65) GAACYP19A1CYP3A4TSHRNFKB1
SCHEMBL3209768 0.85 GAA (0.60) GAACYP19A1CYP3A4TSHRNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 214 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4230201-A1 COMPOSITION FOR TREATING NEURODEGENERATIVE DISEASES UNIVERSIDADE NOVA DE LISBOA (PT) 2023-08-23 EP claimed
CN-112409974-B Amphiphilic bio-based degradable underwater adhesive and preparation method and application thereof 江南大学 2021-12-21 CN claimed
CN-112409974-A Amphiphilic bio-based degradable underwater adhesive and preparation method and application thereof 江南大学 2021-02-26 CN claimed
US-20040176472-A1 Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof AJINOMOTO CO., INC. (JP) 2004-09-09 US claimed
US-20030199566-A1 Phenolic acid derivatives and composition for preventing or treating blood lipid level-related diseases comprising the same BIONUTRIGEN CO., LTD. (KR) 2003-10-23 US claimed
US-20020133037-A1 Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof AJINOMOTO CO. INC (JP) 2002-09-19 US claimed
EP-1231215-A1 PROCESS FOR THE PRODUCTION OF ASPARTYLDIPEPTIDE ESTER DERIVATIVES, NOVEL INTERMEDIATES THEREFOR AND PROCESS FOR THE PRODUCTION OF THE INTERMEDIATES Ajinomoto Co., Inc. (JP) 2002-08-14 EP claimed
US-20250162986-A1 Compounds and compositions for neurodegenerative diseases UNIVERSIDADE NOV A DE LISBOA (PT) 2025-05-22 US disclosed
EP-4482483-A1 COMPOUNDS AND COMPOSITIONS FOR NEURODEGENERATIVE DISEASES UNIVERSIDADE NOVA DE LISBOA (PT) 2025-01-01 EP disclosed
CN-118742304-A Compounds and compositions for neurodegenerative diseases 里斯本新大学 2024-10-01 CN disclosed
CN-117990868-A Method for evaluating influence of yoghurt on flavone and phenolic acid in orange juice by adopting in-vitro model simulating gastrointestinal digestion 上海交通大学医学院 2024-05-07 CN disclosed
CN-116535366-B Thiazole compound and preparation method and application thereof 广州医科大学 2023-12-05 CN disclosed
US-11746364-B2 Enzymatic synthesis of kavalactones and flavokavains WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2023-09-05 US disclosed
US-20030009050-A1 Crystals of aspartame derivative AJINOMOTO CO. INC. (JP) 2003-01-09 US disclosed
EP-1245573-A1 ASPARTAME DERIVATIVE CRYSTALS Ajinomoto Co., Inc. (JP) 2002-10-02 EP disclosed
US-20020133037-A1 Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof AJINOMOTO CO. INC (JP) 2002-09-19 US disclosed
EP-1231215-A1 PROCESS FOR THE PRODUCTION OF ASPARTYLDIPEPTIDE ESTER DERIVATIVES, NOVEL INTERMEDIATES THEREFOR AND PROCESS FOR THE PRODUCTION OF THE INTERMEDIATES Ajinomoto Co., Inc. (JP) 2002-08-14 EP disclosed
US-6150412-A SUCH AS 4-(5-HYDROXY-4-METHOXY-2-NITROPHENYL)BUTANOIC ACID; ADMINISTERING TO INHIBIT CATECHOL-O-METHYL TRANSFERASE; TREATING PARKINSON'S DISEASE OR HYPERTENSION ORION-YHTYMA OY (FI) 2000-11-21 US disclosed
WO-1996037456-A1 NEW CATECHOL DERIVATIVES Orion-Yhtymä Oy (FI) 1996-11-28 WO disclosed
US-4026896-A ANTIALLERGENS KISSEI YAKUHIN KOGYO KABUSHIKI KAISHA (KISSEI PHARMACEUTICAL CO. LTD.) (JA) 1977-05-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020133037-A1 Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof DPP4, DNPEP, IAPP GAA 882/4885CYP19A1 3026/4885CYP3A4 1255/4885
US-20030199566-A1 Phenolic acid derivatives and composition for preventing or treating blood lipid level-related diseases comprising the same NCEH1, HMGCR, DBH GAA 3136/4885CYP19A1 1081/4885CYP3A4 185/4885
US-20250162986-A1 Compounds and compositions for neurodegenerative diseases CLN6, HTT, SNCA GAA 57/4885CYP19A1 4551/4885CYP3A4 4863/4885
US-20030009050-A1 Crystals of aspartame derivative DNPEP, TASP1, DPP4 GAA 425/4885CYP19A1 4680/4885CYP3A4 1874/4885
US-20040176472-A1 Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof DPP4, DNPEP, IAPP GAA 882/4885CYP19A1 3026/4885CYP3A4 1255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.