Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4910029 | 0.83 | GPBAR1 (0.39) | KDM4EALDH1A1MAPK1CYP1A2GPBAR1 | |
| SCHEMBL4901147 | 0.83 | KDM4E (0.38) | KDM4EALDH1A1MAPK1RAD52GPBAR1 | |
| SCHEMBL4911878 | 0.81 | GPBAR1 (0.34) | KDM4EALDH1A1MAPK1GPBAR1 | |
| SCHEMBL4906946 | 0.80 | GPBAR1 (0.41) | ALDH1A1MAPK1GPBAR1 | |
| SCHEMBL4902269 | 0.80 | PTPN2 (0.35) | KDM4EALDH1A1MAPK1CYP3A4GPBAR1 | |
| SCHEMBL4910046 | 0.78 | BRD4 (0.36) | KDM4EALDH1A1MAPK1CYP2D6GPBAR1 | |
| SCHEMBL4902302 | 0.76 | TSHR (0.41) | ALDH1A1MAPK1GPBAR1 | |
| SCHEMBL4907240 | 0.76 | GPBAR1 (0.42) | ALDH1A1MAPK1GPBAR1 | |
| SCHEMBL4912334 | 0.76 | GPBAR1 (0.42) | ALDH1A1MAPK1GPBAR1 | |
| SCHEMBL4910164 | 0.76 | ALDH1A1 (0.37) | ALDH1A1MAPK1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076760-A1 | 2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION | WAKAMOTO PHARMACEUTICAL CO., LTD (JP) | 2008-03-27 | — | — | US | disclosed |
| EP-1820799-A1 | 2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION | Wakamoto Pharmaceutical Co., Ltd. (JP) | 2007-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076760-A1 | 2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION | GABRA5, GABRA1, GABRB1 | KDM4E 2138/4885ALDH1A1 492/4885MAPK1 1327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.