Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 5/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903050 | 0.90 | STAT3 (0.43) | TSHRCAMK2ASTAT3 | |
| SCHEMBL4902618 | 0.81 | ALDH1A1 (0.46) | ALDH1A1TSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL4906721 | 0.81 | ALDH1A1 (0.46) | ALDH1A1TSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL4903045 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL4907392 | 0.78 | TDP1 (0.47) | ALDH1A1TSHRSMN1; SMN2TDP1HTT | |
| SCHEMBL4909548 | 0.78 | MMP9 (0.48) | ALDH1A1TSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL4911887 | 0.73 | ALDH1A1 (0.39) | ALDH1A1TSHRSMN1; SMN2TDP1HTT | |
| SCHEMBL4900736 | 0.72 | TSHR (0.39) | ALDH1A1TSHRSMN1; SMN2TDP1HTT | |
| SCHEMBL4899484 | 0.72 | ALDH1A1 (0.39) | ALDH1A1TSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL4899843 | 0.71 | LMNA (0.44) | ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | HAMANAKA ERNEST S | 2006-10-12 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARA, PPARG, PPARD | ALDH1A1 2664/4885TSHR 412/4885CAMK2A 2334/4885 |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | ALDH1A1 2956/4885TSHR 400/4885CAMK2A 2101/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | ALDH1A1 2956/4885TSHR 400/4885CAMK2A 2101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.