Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 18/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906218 | 0.92 | TRPM8 (0.45) | TRPM8 | |
| SCHEMBL4900544 | 0.91 | KDM4E (0.41) | RORC | |
| SCHEMBL4907462 | 0.91 | TRPM8 (0.43) | TRPM8RORCHCRTR2 | |
| SCHEMBL4895425 | 0.90 | TRPM8 (0.39) | TRPM8 | |
| SCHEMBL4899693 | 0.90 | TP53 (0.40) | TRPM8 | |
| SCHEMBL4905887 | 0.88 | TRPM8 (0.42) | TRPM8RORCHCRTR2 | |
| SCHEMBL4895175 | 0.88 | MAPT (0.36) | TRPM8HCRTR2 | |
| SCHEMBL4901291 | 0.88 | ALDH1A1 (0.39) | TRPM8 | |
| SCHEMBL4898017 | 0.88 | L3MBTL1 (0.41) | TRPM8 | |
| SCHEMBL4906570 | 0.86 | SLC6A3 (0.39) | TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | HAMANAKA ERNEST S | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARA, PPARG, PPARD | TRPM8 4270/4885RORC 82/4885HCRTR2 3924/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | TRPM8 4317/4885RORC 87/4885HCRTR2 3933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.