Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13694250 | 0.93 | AKT1 (0.56) | AKT1ATMPOLBCA2KDM4E | |
| SCHEMBL14270293 | 0.92 | AKT1 (0.51) | AKT1ATMPOLBCA2KDM4E | |
| SCHEMBL11290729 | 0.83 | GABRA1 (0.55) | AKT1ATMPOLBCA2KDM4E | |
| SCHEMBL1332082 | 0.82 | ATM (0.66) | ATMPOLBCA2KDM4ECYP1A2 | |
| SCHEMBL4615833 | 0.82 | AKT1 (0.45) | AKT1ATMPOLBKDM4ECYP1A2 | |
| SCHEMBL4672811 | 0.79 | ATM (0.45) | ATMPOLBCA2KDM4ECYP19A1 | |
| SCHEMBL8938305 | 0.78 | TSHR (0.69) | CYP1A2CYP3A4CYP19A1GAATSHR | |
| SCHEMBL14144881 | 0.78 | MAPT (0.51) | ATMPOLBKDM4ECYP1A2CYP3A4 | |
| SCHEMBL28186288 | 0.78 | GAA (0.67) | ATMPOLBCA2KDM4ECYP1A2 | |
| SCHEMBL30135970 | 0.78 | GAA (0.67) | ATMPOLBCA2KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221702-A1 | COMPOUNDS | IMPERIAL INNOVATIONS LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
| US-20080039527-A1 | Calixarenes as Inhibitors of Protein Kinase B | IMPERIAL COLLEGE INNOVATIONS LTD. | 2008-02-14 | — | — | US | disclosed |
| US-20080039527-A1 | Calixarenes as Inhibitors of Protein Kinase B | IMPERIAL COLLEGE INNOVATIONS LTD. | 2008-02-14 | — | — | US | disclosed |
| US-20080039527-A1 | Calixarenes as Inhibitors of Protein Kinase B | IMPERIAL COLLEGE INNOVATIONS LTD. | 2008-02-14 | — | — | US | disclosed |
| EP-1687255-A2 | CALIXARENES AS INHIBITORS OF PROTEIN KINASE B | Imperial College Innovations Limited (GB) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005023744-A2 | CALIXARENES AS INHIBITORS OF PROTEIN KINASE B | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039527-A1 | Calixarenes as Inhibitors of Protein Kinase B | CAMK2B, PNCK, CAMK1 | AKT1 25/4885ATM 766/4885POLB 2094/4885 |
| US-20090221702-A1 | COMPOUNDS | NCEH1, NME2, HRH3 | AKT1 33/4885ATM 2486/4885POLB 3733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.