Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8694267 | 0.99 | TACR1 (0.45) | TACR1CYP2D6SLC6A3DRD2SLC6A2 | |
| SCHEMBL6702675 | 0.87 | SLC6A2 (0.40) | TACR1DRD2SLC6A2SLC6A4SCN9A | |
| Hydrochloric Acid SCHEMBL4914596 | 0.86 | SLC6A2 (0.40) | TACR1DRD2SLC6A2KCNH2SLC6A4 | |
| SCHEMBL7256713 | 0.86 | TACR1 (0.39) | TACR1CYP2D6SLC6A3DRD2KCNH2 | |
| SCHEMBL27365754 | 0.85 | TACR1 (0.53) | TACR1CYP2D6MEN1KMT2A | |
| SCHEMBL7257076 | 0.85 | TACR1 (0.38) | TACR1CYP2D6SLC6A3SLC6A2KCNH2 | |
| SCHEMBL6154253 | 0.85 | TACR1 (0.39) | TACR1CYP2D6SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL7837990 | 0.84 | TACR1 (0.52) | TACR1CYP2D6KCNH2MEN1KMT2A | |
| SCHEMBL9420110 | 0.83 | TACR1 (0.36) | TACR1CYP2D6SLC6A3DRD2SLC6A2 | |
| SCHEMBL6931695 | 0.83 | TACR1 (0.52) | TACR1CYP2D6SLC6A3KCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080132538-A1 | Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles | PFIZER INC | 2008-06-05 | — | — | US | claimed |
| US-20050256162-A1 | Fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles | PFIZER INC | 2005-11-17 | — | — | US | claimed |
| EP-1027892-B1 | Azithromycin combination for emesis control in dogs | PFIZER PROD INC (US) | 2005-08-17 | — | — | EP | claimed |
| US-20030199540-A1 | Fluoroalkyoxybenzylamino derivatives of nitrogen containing heterocycles | LOWE JOHN ADAMS (US) | 2003-10-23 | — | — | US | claimed |
| US-20030114439-A1 | Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles | PFIZER INC. | 2003-06-19 | — | — | US | claimed |
| US-20020035147-A1 | Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles | PFIZER INC. | 2002-03-21 | — | — | US | claimed |
| EP-1172106-A2 | Use of fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles as substance P receptor antagonists | Pfizer Products Inc. (US) | 2002-01-16 | — | — | EP | claimed |
| EP-0589924-B1 | FLUOROALKOXYBENZYLAMINO DERIVATIVES OF NITROGEN CONTAINING HETEROCYCLES | PFIZER (US) | 1996-09-04 | — | — | EP | claimed |
| EP-0589924-A1 | FLUOROALKOXYBENZYLAMINO DERIVATIVES OF NITROGEN CONTAINING HETEROCYCLES. | PFIZER (US) | 1994-04-06 | — | — | EP | claimed |
| EP-1172106-A2 | Use of fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles as substance P receptor antagonists | Pfizer Products Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| US-5744480-A | ANTIINFLAMMATORY AGENTS, NERVOUS SYSTEM DISORDERS | PFIZER INC. (US) | 1998-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199540-A1 | Fluoroalkyoxybenzylamino derivatives of nitrogen containing heterocycles | FPR1, OPRK1, CNR1 | TACR1 517/4885CYP2D6 343/4885SLC6A3 255/4885 |
| US-20080132538-A1 | Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles | NMUR2, NMUR1, NMBR | TACR1 41/4885CYP2D6 723/4885SLC6A3 78/4885 |
| US-20020035147-A1 | Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles | AQP4, NAT1, CNR1 | TACR1 212/4885CYP2D6 61/4885SLC6A3 46/4885 |
| US-20030114439-A1 | Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles | AQP4, NAT1, CNR1 | TACR1 212/4885CYP2D6 61/4885SLC6A3 46/4885 |
| US-20050256162-A1 | Fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles | FPR3, CX3CR1, FPR1 | TACR1 564/4885CYP2D6 319/4885SLC6A3 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.