Sugi Predict

Sugi Predict / Compounds / SCHEMBL4908223

SCHEMBL4908223

SCHEMBL4908223

CCN(Sc1ccc(Oc2ccc(F)cc2)cc1)S(=O)(=O)c1cc(C)c(C)c(C(=O)O)c1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TAS2R14 Q9NYV8 1/20 0.36
▸ FFAR1 O14842 1/20 0.35
▸ LMNA P02545 3/20 0.35
▸ HPGD P15428 1/20 0.34
▸ MCL1 Q07820 7/20 0.34
▸ BCL2L1 Q07817 5/20 0.34
▸ HTT P42858 2/20 0.34
▸ POLB P06746 2/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ APEX1 P27695 1/20 0.34
▸ CTDSP1 Q9GZU7 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ NR3C1 P04150 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4905862 0.92 POLB (0.41) TAS2R14LMNAMCL1BCL2L1HTT
SCHEMBL4907422 0.92 MCL1 (0.41) LMNAHPGDMCL1BCL2L1HTT
SCHEMBL4906808 0.92 MMP9 (0.36) LMNAMCL1BCL2L1HTT
SCHEMBL4902549 0.91 LMNA (0.38) LMNAMCL1BCL2L1HTTPOLB
SCHEMBL4905600 0.91 ALDH1A1 (0.38) FFAR1LMNAHPGDHTTNPC1
SCHEMBL4904426 0.90 TDP1 (0.36) LMNAMCL1BCL2L1HTTPOLB
SCHEMBL4906155 0.90 MCL1 (0.35) TAS2R14LMNAMCL1BCL2L1HTT
SCHEMBL4902550 0.89 TRPM8 (0.38) NR3C1KDM4E
SCHEMBL4902749 0.89 PPARD (0.37) —
SCHEMBL4905969 0.89 POLB (0.43) TAS2R14FFAR1LMNAHPGDMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US claimed
EP-1765796-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS Pfizer Products Inc. (US) 2007-03-28 — — EP claimed
WO-2006003495-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER PRODUCTS INC. (US) 2006-01-12 — — WO claimed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US claimed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD TAS2R14 4063/4885FFAR1 110/4885LMNA 317/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD TAS2R14 4032/4885FFAR1 101/4885LMNA 319/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD TAS2R14 4032/4885FFAR1 101/4885LMNA 319/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.