Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.35 |
| ▸ | FPR3 | P25089 | 4/20 | 0.33 |
| ▸ | FPR2 | P25090 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490915 | 0.83 | AAK1 (0.47) | PTPN11AAK1 | |
| SCHEMBL490856 | 0.78 | CTSK (0.39) | CACNA1BCTSSCTSKSMN1; SMN2ALDH1A1 | |
| SCHEMBL490586 | 0.78 | CACNA1B (0.41) | CACNA1BCTSSCTSKNPC1RECQL | |
| SCHEMBL490921 | 0.77 | NPC1 (0.42) | CACNA1BCTSSCTSKNPC1RECQL | |
| SCHEMBL4848663 | 0.73 | EPHX1 (0.40) | CACNA1BCTSSCTSKSMN1; SMN2ALDH1A1 | |
| SCHEMBL4848668 | 0.73 | EPHX1 (0.40) | CACNA1BCTSSCTSKSMN1; SMN2ALDH1A1 | |
| SCHEMBL490571 | 0.73 | AKT1 (0.41) | CACNA1BCTSSCTSKKMT2AL3MBTL1 | |
| SCHEMBL376033 | 0.72 | CTSS (0.40) | CACNA1BCTSSCTSKAAK1ALDH1A1 | |
| SCHEMBL375865 | 0.72 | CTSS (0.40) | CACNA1BCTSSCTSKAAK1ALDH1A1 | |
| SCHEMBL5320288 | 0.72 | KMT2A (0.46) | CACNA1BCTSSCTSKKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106091-B2 | Inhibitors of IKK-beta serine-threonine protein kinase | CHROMA THERAPEUTICS LTD. (GB) | 2012-01-31 | — | — | US | disclosed |
| EP-2086956-B1 | INHIBITORS OF IKK- BETA SERINE-THREONINE PROTEIN KINASE | CHROMA THERAPEUTICS LTD (GB) | 2011-09-14 | — | — | EP | disclosed |
| US-20100069473-A1 | Inhibitors Of IKK-Beta Serine-Threonine Protein Kinase | CHROMA THERAPEUTICS LTD. (GB) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069473-A1 | Inhibitors Of IKK-Beta Serine-Threonine Protein Kinase | IKBKB, IKBKE, CHUK | PTPN11 670/4885CACNA1B 2344/4885CTSS 2844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.