Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18855182 | 0.80 | CHRM5 (0.36) | CHRM5CHRM3SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL3822012 | 0.80 | SIGMAR1 (0.36) | CHRM5CHRM3SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL17916212 | 0.80 | OPRL1 (0.40) | CHRM5CHRM3SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL27629556 | 0.78 | SLC6A4 (0.32) | CHRM5CHRM3SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL22414139 | 0.78 | SMN1; SMN2 (0.33) | CHRM5CHRM3SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL9801277 | 0.78 | SLC6A4 (0.32) | CHRM5CHRM3SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL4260116 | 0.78 | CHRM5 (0.35) | CHRM5CHRM3SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL5543241 | 0.78 | CHRM5 (0.33) | CHRM5CHRM3SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL4236959 | 0.78 | CHRM5 (0.33) | CHRM5CHRM3SIGMAR1SLC6A4SLC6A2 | |
| SCHEMBL5197504 | 0.77 | MEN1 (0.33) | CHRM5CHRM3SIGMAR1SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076760-A1 | 2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION | WAKAMOTO PHARMACEUTICAL CO., LTD (JP) | 2008-03-27 | — | — | US | disclosed |
| EP-1820799-A1 | 2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION | Wakamoto Pharmaceutical Co., Ltd. (JP) | 2007-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076760-A1 | 2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION | GABRA5, GABRA1, GABRB1 | CHRM5 851/4885CHRM3 857/4885SIGMAR1 759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.