Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5798907 | 1.00 | HCAR2 (0.54) | HCAR2LMNAMAPK1CES2CES1 | |
| SCHEMBL9764591 | 0.95 | LMNA (0.52) | HCAR2LMNAMAPK1CES2CES1 | |
| SCHEMBL28905351 | 0.83 | LMNA (0.51) | HCAR2LMNAMAPK1CYP2D6CYP2C9 | |
| SCHEMBL352390 | 0.81 | LMNA (0.62) | LMNAMAPK1CES2CES1HPGD | |
| SCHEMBL1951103 | 0.81 | LMNA (0.62) | LMNAMAPK1CES2CES1HPGD | |
| Mandelic Acid SCHEMBL4909583 | 0.77 | LMNA (0.78) | HCAR2LMNAMAPK1CES2CES1 | |
| Mandelic Acid SCHEMBL4909573 | 0.77 | LMNA (0.78) | HCAR2LMNAMAPK1CES2CES1 | |
| Mandelic Acid SCHEMBL5798900 | 0.77 | LMNA (0.78) | HCAR2LMNAMAPK1CES2CES1 | |
| SCHEMBL2687707 | 0.77 | LMNA (0.58) | LMNAMAPK1CES2CES1HPGD | |
| SCHEMBL378836 | 0.74 | LMNA (0.54) | LMNAMAPK1CES2CES1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080124404-A1 | Hypolipidemic and/or hypocholesteremic compounds obtainable from the goldenseal plant | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080124404-A1 | Hypolipidemic and/or hypocholesteremic compounds obtainable from the goldenseal plant | LIPA, HMGCR, LCAT | HCAR2 149/4885LMNA 2396/4885MAPK1 3441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.