Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3981999 | 0.84 | KDM4E (0.50) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| Dipyridyl SCHEMBL4954412 | 0.81 | KDM4E (0.56) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| SCHEMBL28453174 | 0.72 | KDM4E (0.49) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| SCHEMBL28449259 | 0.72 | KDM4E (0.53) | KDM4EALDH1A1NPC1LMNACYP1A2 | |
| SCHEMBL4657861 | 0.71 | KDM4E (0.50) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| SCHEMBL8546751 | 0.71 | KDM4E (0.42) | KDM4EALDH1A1NPC1LMNACYP1A2 | |
| Dipyridyl SCHEMBL4881410 | 0.70 | KDM4E (0.67) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| Dipyridyl SCHEMBL9641711 | 0.70 | KDM4E (0.67) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| Dipyridyl SCHEMBL11231947 | 0.70 | KDM4E (0.67) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| SCHEMBL3143645 | 0.70 | KDM4E (0.49) | KDM4EKDM6BKDM4AKDM5CKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058579-A1 | Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors | ANGIOTECH INTERNATIONAL AG (CH) | 2008-03-06 | — | — | US | disclosed |
| US-20030144570-A1 | Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors | ANGIOTECH PHARMACEUTICALS, INC. (CA) | 2003-07-31 | — | — | US | disclosed |
| US-20020055666-A1 | Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors | ANGIOTECH INTERNATIONAL AG (CH) | 2002-05-09 | — | — | US | disclosed |