Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4911505 | 0.83 | ALDH1A1 (0.40) | ALDH1A1MAPTAMY1AHTTKDM4E | |
| Dimethylamine SCHEMBL4911507 | 0.81 | ALDH1A1 (0.40) | ALDH1A1MAPTAMY1AHTTLMNA | |
| SCHEMBL4903308 | 0.73 | ALDH1A1 (0.39) | ALDH1A1MAPTAMY1AHTTSMN1; SMN2 | |
| SCHEMBL241748 | 0.70 | KMT2A (0.36) | ALDH1A1HTTLMNAKDM4EKMT2A | |
| SCHEMBL240953 | 0.69 | ALDH1A1 (0.33) | ALDH1A1HTTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL4910912 | 0.68 | MAPT (0.38) | ALDH1A1MAPTAMY1ASMN1; SMN2LMNA | |
| SCHEMBL13996173 | 0.65 | ALDH1A1 (0.36) | ALDH1A1MAPTHTTLMNAKDM4E | |
| SCHEMBL4903280 | 0.61 | TXNRD1 (0.47) | ALDH1A1SMN1; SMN2ABCG2 | |
| SCHEMBL17478755 | 0.60 | ALDH1A1 (0.71) | ALDH1A1MAPTAMY1AHTTKMT2A | |
| SCHEMBL5779054 | 0.60 | L3MBTL1 (0.48) | ALDH1A1MAPTHTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2008-02-21 | — | — | US | disclosed |
| US-6992089-B2 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE UNIVERSITY OF NEW JERSEY (US) | 2006-01-31 | — | — | US | disclosed |
| US-20040102443-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | TOP1, TOP2A, TOP2B | ALDH1A1 2380/4885MAPT 4024/4885AMY1A 3370/4885 |
| US-20040102443-A1 | Nitro and amino substituted topoisomerase agents | TOP1, TOP2A, TOP2B | ALDH1A1 1476/4885MAPT 4283/4885AMY1A 2151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.