Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.37 |
| ▸ | CHRNG | P07510 | 3/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14197190 | 1.00 | CFTR (0.40) | CFTRKDM4EALDH1A1GAAPOLB | |
| SCHEMBL4907621 | 1.00 | CFTR (0.40) | CFTRKDM4EALDH1A1GAAPOLB | |
| SCHEMBL14197193 | 1.00 | CFTR (0.40) | CFTRKDM4EALDH1A1GAAPOLB | |
| SCHEMBL4907622 | 1.00 | CFTR (0.40) | CFTRKDM4EALDH1A1GAAPOLB | |
| SCHEMBL4909081 | 0.84 | RXRB (0.46) | KDM4EALDH1A1HPGDATMHSD17B10 | |
| SCHEMBL14197189 | 0.84 | RXRB (0.46) | KDM4EALDH1A1HPGDATMHSD17B10 | |
| SCHEMBL14197188 | 0.84 | RXRB (0.46) | KDM4EALDH1A1HPGDATMHSD17B10 | |
| SCHEMBL4908072 | 0.84 | RXRB (0.46) | KDM4EALDH1A1HPGDATMHSD17B10 | |
| SCHEMBL20556211 | 0.79 | SLC6A3 (0.43) | KDM4EALDH1A1GAAGLAMAPT | |
| SCHEMBL4899708 | 0.77 | RAB9A (0.51) | KDM4EALDH1A1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080096919-A1 | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | RENOVIS, INC. | 2008-04-24 | — | — | US | disclosed |
| US-7312233-B2 | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | RENOVIS, INC. (US) | 2007-12-25 | — | — | US | disclosed |
| US-20060205773-A1 | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | EVOTEC AG (DE) | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205773-A1 | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | TRPV1, TRPA1, TRPV2 | CFTR 141/4885KDM4E 4112/4885ALDH1A1 1821/4885 |
| US-20080096919-A1 | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | TRPV1, TRPA1, TRPV2 | CFTR 141/4885KDM4E 4112/4885ALDH1A1 1821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.