Sugi Predict

Sugi Predict / Compounds / SCHEMBL491296

SCHEMBL491296

SCHEMBL491296

CCOC(=O)C(C(=O)OC(C)(C)C)c1cc(Br)cc(OCc2ccccc2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.46
▸ L3MBTL1 Q9Y468 1/20 0.46
▸ LTA4H P09960 1/20 0.42
▸ MAOB P27338 2/20 0.40
▸ MMP8 P22894 2/20 0.40
▸ NR1H4 Q96RI1 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ PRKCA P17252 1/20 0.40
▸ PRKCD Q05655 1/20 0.40
▸ KMT2A Q03164 4/20 0.40
▸ MEN1 O00255 3/20 0.40
▸ PSEN1 P49768 1/20 0.39
▸ PSEN2 P49810 1/20 0.39
▸ APH1B Q8WW43 1/20 0.39
▸ NCSTN Q92542 1/20 0.39
▸ APH1A Q96BI3 1/20 0.39
▸ PSENEN Q9NZ42 1/20 0.39
▸ HSP90AA1 P07900 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7811580 0.78 LMNA (0.53) LMNAL3MBTL1MAOBMMP8NR1H4
SCHEMBL16795576 0.76 MMP8 (0.60) MMP8KMT2AMEN1SMN1; SMN2
SCHEMBL2716599 0.75 LMNA (0.68) LMNAL3MBTL1MAOBMMP8NR1H4
SCHEMBL348286 0.74 LMNA (0.51) LMNAL3MBTL1MMP8NR1H4ALDH1A1
SCHEMBL29134320 0.74 MMP8 (0.47) LMNAMMP8ALDH1A1KMT2AMEN1
SCHEMBL646425 0.73 MYC (0.44) LMNAL3MBTL1ALDH1A1KMT2AMEN1
SCHEMBL2434981 0.73 ITGA4 (0.39) LMNAL3MBTL1LTA4HALDH1A1KMT2A
SCHEMBL11099357 0.72 LTA4H (0.56) LMNAL3MBTL1LTA4HMAOBPRKCA
SCHEMBL491321 0.72 NR1H4 (0.49) LMNAL3MBTL1MAOBNR1H4ALDH1A1
SCHEMBL27461095 0.72 LMNA (0.57) LMNAL3MBTL1LTA4HMAOBMMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2021314-B1 SUBSTITUTED BIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES THEREOF ORTHO MCNEIL JANSSEN PHARM (US) 2013-01-23 — — EP disclosed
EP-2016039-B1 TERPHENYL DERIVATIVES FOR TREATMENT OF ALZHEIMER' S DISEASE ORTHO MCNEIL JANSSEN PHARM (US) 2012-08-01 — — EP disclosed
CN-101084178-B (biphenyl) carboxylic acids and derivatives thereof CELLZOME AG 2012-03-28 — — CN disclosed
US-8106236-B2 Triaryl compounds and derivates thereof ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2012-01-31 — — US disclosed
US-7825160-B2 such as [5-(4-Fluoro-benzyloxy)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid, used for the treatment of Alzheimer's disease and for the modulation of gamma -secretase activity CELLZOME LIMITED (GB) 2010-11-02 — — US disclosed
EP-1847524-B1 Terphenyl derivatives for treatment of Alzheimer's disease CELLZOME LTD (GB) 2009-10-14 — — EP disclosed
EP-1849762-B1 Substituted biphenyl carboxylic acids and derivatives thereof CELLZOME LTD (GB) 2009-07-15 — — EP disclosed
US-7557244-B2 Substituted biphenyl carboxylic acids and derivatives thereof ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2009-07-07 — — US disclosed
US-20090118289-A1 (Biphenyl) Carboxylic Acids and Derivatives Thereof CELLZOME AG (DE) 2009-05-07 — — US disclosed
EP-1805129-B1 (BIPHENYL) CARBOXYLIC ACIDS AND DERIVATIVES THEREOF CELLZOME LTD (GB) 2009-03-18 — — EP disclosed
EP-2016039-A1 TERPHENYL DERIVATIVES FOR TREATMENT OF ALZHEIMER' S DISEASE Ortho-Mcneil Pharmaceutical, Inc. (US) 2009-01-21 — — EP disclosed
US-20070293567-A1 SUBSTITUTED BIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES THEREOF ORTHO-MCNEIL PHARMACEUTICAL, INC. 2007-12-20 — — US disclosed
CN-101084178-A (Biphenyl) carboxylic acids and derivatives thereof CELLZOME AG (DE) 2007-12-05 — — CN disclosed
WO-2007124351-A1 TERPHENYL DERIVATIVES FOR TREATMENT OF ALZHEIMER' S DISEASE ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2007-11-01 — — WO disclosed
US-20070254957-A1 TRIARYL COMPOUNDS AND DERIVATES THEREOF ORTHO-MCNEIL PHARMACEUTICAL, INC. 2007-11-01 — — US disclosed
WO-2007124394-A1 SUBSTITUTED BIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES THEREOF ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2007-11-01 — — WO disclosed
EP-1849762-A1 Substituted biphenyl carboxylic acids and derivatives thereof Cellzome (UK) Ltd. (GB) 2007-10-31 — — EP disclosed
EP-1847524-A1 Terphenyl derivatives for treatment of Alzheimer's disease Cellzome (UK) Ltd. (GB) 2007-10-24 — — EP disclosed
EP-1805129-A1 (BIPHENYL) CARBOXYLIC ACIDS AND DERIVATIVES THEREOF CELLZOME AG (DE) 2007-07-11 — — EP disclosed
WO-2006045554-A1 (BIPHENYL) CARBOXYLIC ACIDS AND DERIVATIVES THEREOF CELLZOME AG (DE) 2006-05-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070293567-A1 SUBSTITUTED BIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES THEREOF BACE1, BACE2, APP LMNA 1794/4885L3MBTL1 2515/4885LTA4H 2013/4885
US-20090118289-A1 (Biphenyl) Carboxylic Acids and Derivatives Thereof BACE1, BACE2, APP LMNA 1983/4885L3MBTL1 3056/4885LTA4H 1410/4885
US-20070254957-A1 TRIARYL COMPOUNDS AND DERIVATES THEREOF BACE1, BACE2, APP LMNA 1012/4885L3MBTL1 2180/4885LTA4H 958/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.