Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4924535 | 0.91 | NOTUM (0.46) | MAPK1NPC1RAB9ACHRNA7CNR1 | |
| SCHEMBL14270596 | 0.84 | CNR1 (0.53) | MAPTMAPK1NPC1CHRNA7CNR1 | |
| SCHEMBL4923406 | 0.83 | CNR1 (0.57) | CNR1 | |
| SCHEMBL6071579 | 0.78 | CHRNA7 (0.63) | MAPTMAPK1NPC1RAB9ACHRNA7 | |
| SCHEMBL4492901 | 0.76 | MAPK1 (0.67) | MAPTMAPK1NPC1RAB9ACHRNA7 | |
| SCHEMBL4244093 | 0.75 | CNR1 (0.55) | CHRNA7CNR1 | |
| SCHEMBL14270597 | 0.74 | CNR1 (0.56) | CHRNA7CNR1NOTUM | |
| SCHEMBL4918783 | 0.73 | MAPK1 (0.60) | MAPTMAPK1NPC1RAB9ACHRNA7 | |
| SCHEMBL13574377 | 0.73 | CHRNA7 (0.61) | MAPTMAPK1NPC1RAB9ACHRNA7 | |
| SCHEMBL4924236 | 0.73 | MAPK1 (0.57) | MAPTMAPK1NPC1RAB9ACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051433-A1 | Pyrrole-3-Carboxamide Derivatives for the Treatment of Obesity | ASTRAZENECA (SE) | 2008-02-28 | — | — | US | disclosed |
| EP-1718610-A1 | PYRROLE-3-CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY | AstraZeneca AB (SE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005080328-A1 | PYRROLE-3-CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051433-A1 | Pyrrole-3-Carboxamide Derivatives for the Treatment of Obesity | PC, GPR119, PGC | MAPT 639/4885MAPK1 3403/4885NPC1 785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.