Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 11/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | MARS1 | P56192 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4914787 | 0.91 | MAPT (0.48) | NOTUMCNR1ALDH1A1HPGDMAPK1 | |
| SCHEMBL4923406 | 0.86 | CNR1 (0.57) | CNR1 | |
| SCHEMBL14270597 | 0.83 | CNR1 (0.56) | NOTUMCNR1CHRNA7MARS1 | |
| SCHEMBL5922313 | 0.76 | CHRNA7 (0.56) | NOTUMALDH1A1HPGDMAPK1TDP1 | |
| SCHEMBL4244093 | 0.76 | CNR1 (0.55) | CNR1CHRNA7 | |
| SCHEMBL4244095 | 0.75 | CNR1 (0.52) | CNR1CHRNA7 | |
| SCHEMBL14270596 | 0.74 | CNR1 (0.53) | CNR1ALDH1A1MAPK1CHRNA7NPC1 | |
| SCHEMBL4465707 | 0.72 | NOTUM (0.63) | NOTUMCNR1ALDH1A1HPGDMAPK1 | |
| SCHEMBL14270595 | 0.70 | CNR1 (0.74) | CNR1 | |
| SCHEMBL5922340 | 0.69 | CHRNA7 (0.54) | NOTUMCNR1ALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051433-A1 | Pyrrole-3-Carboxamide Derivatives for the Treatment of Obesity | ASTRAZENECA (SE) | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051433-A1 | Pyrrole-3-Carboxamide Derivatives for the Treatment of Obesity | PC, GPR119, PGC | NOTUM 544/4885CNR1 143/4885ALDH1A1 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.