Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2658522 | 0.94 | KDM4E (0.56) | POLBLMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL3438747 | 0.93 | POLB (0.47) | POLBLMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL8435356 | 0.93 | KDM4E (0.54) | POLBLMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL10390508 | 0.93 | KDM4E (0.54) | POLBLMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL6041286 | 0.93 | KDM4E (0.54) | POLBLMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL23014971 | 0.93 | KDM4E (0.54) | POLBLMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL10390555 | 0.90 | POLB (0.47) | POLBLMNAALDH1A1IDO1CA2 | |
| SCHEMBL6616820 | 0.90 | KDM4E (0.45) | POLBLMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL6589802 | 0.88 | CA1 (0.66) | POLBLMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL9574195 | 0.88 | TDP1 (0.50) | POLBLMNAALDH1A1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11623920-B2 | Process for preparing pitolisant hydrochloride and solid-state forms thereof | NURAY CHEMICALS PRIVATE LIMITED (IN) | 2023-04-11 | — | — | US | claimed |
| CN-107473993-A | The preparation method of high-purity m-trifluoromethyl phenylpropanol methanesulfonates | 山东新华制药股份有限公司 | 2017-12-15 | — | — | CN | claimed |
| CN-105461569-B | A kind of alverine citrate novel crystal forms and preparation method thereof | 南京海融医药科技股份有限公司 | 2017-06-06 | — | — | CN | claimed |
| CN-102584801-B | One-pot asymmetric synthesis process of HIV reverse transcriptase inhibitor efavirenz compounds | SHANGHAI INST ORGANIC CHEM | 2015-02-18 | — | — | CN | claimed |
| CN-111170923-B | DL-tryptophan compound, preparation method and application thereof | 上海市伤骨科研究所 | 2023-07-25 | — | — | CN | disclosed |
| US-20230219914-A1 | PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF | Nuray Chemicals Private Limiited (IN) | 2023-07-13 | — | — | US | disclosed |
| US-20230219914-A1 | PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF | Nuray Chemicals Private Limiited (IN) | 2023-07-13 | — | — | US | disclosed |
| US-20220402886-A1 | PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF | Nuray Chemicals Private Lmiited (IN) | 2022-12-22 | — | — | US | disclosed |
| US-11242296-B2 | Decomposition of organic peroxides and hydrogen peroxide by the iron thiolates and related complexes | NUTECH VENTURES (US) | 2022-02-08 | — | — | US | disclosed |
| US-20200181038-A1 | DECOMPOSITION OF ORGANIC PEROXIDES AND HYDROGEN PEROXIDE BY THE IRON THIOLATES AND RELATED COMPLEXES | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2020-06-11 | — | — | US | disclosed |
| CN-111170923-A | DL-tryptophan compounds, preparation method and application thereof | 上海市伤骨科研究所 | 2020-05-19 | — | — | CN | disclosed |
| EP-2019818-B1 | PROCESS FOR THE PRODUCTION OF COMPOUNDS VIA HAZARDOUS INTERMEDIATES IN A SERIES OF MICROREACTORS | DPX HOLDINGS BV (NL) | 2020-03-18 | — | — | EP | disclosed |
| WO-1999025686-A1 | CYCLIC AMINE DERIVATIVES AND THEIR USE AS DRUGS | TEIJIN LIMITED (JP) | 1999-05-27 | — | — | WO | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |
| CN-1117290-A | Bicyclic carboxylic acid leukotriene B4 antagonists | HOFFMANN LA ROCHE (CH) | 1996-02-21 | — | — | CN | disclosed |
| EP-0682662-A1 | BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B 4? ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-22 | — | — | EP | disclosed |
| US-5457124-A | Antiinflammatory agent | HOFFMANN-LA ROCHE INC. (US) | 1995-10-10 | — | — | US | disclosed |
| WO-1995015956-A1 | BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-15 | — | — | WO | disclosed |
| US-4582854-A | BRONCHODILATOR, ANTIINFLAMMATORY AGENT, ANALGESIC | E. R. SQUIBB & SONS, INC. (US) | 1986-04-15 | — | — | US | disclosed |
| US-4221816-A | Method for the control of phytopathogenic fungi using p-(alkoxyalkyl)urea compounds | AMERICAN CYANAMID COMPANY (US) | 1980-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402886-A1 | PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF | PITHD1, MLN, TPP1 | POLB 3751/4885LMNA 2910/4885ALDH1A1 810/4885 |
| US-20230219914-A1 | PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF | PITHD1, MLN, TPP1 | POLB 3751/4885LMNA 2910/4885ALDH1A1 810/4885 |
| US-11623920-B2 | Process for preparing pitolisant hydrochloride and solid-state forms thereof | PITHD1, MLN, TPP1 | POLB 3751/4885LMNA 2910/4885ALDH1A1 810/4885 |
| US-20200181038-A1 | DECOMPOSITION OF ORGANIC PEROXIDES AND HYDROGEN PEROXIDE BY THE IRON THIOLATES AND RELATED COMPLEXES | GPX4, LPO, CAT | POLB 351/4885LMNA 4433/4885ALDH1A1 809/4885 |
| US-11242296-B2 | Decomposition of organic peroxides and hydrogen peroxide by the iron thiolates and related complexes | GPX4, LPO, CAT | POLB 351/4885LMNA 4433/4885ALDH1A1 809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.