SCHEMBL4918384

SCHEMBL4918384

COc1cc(OC)nc(CN)n1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 2/20 0.44
LOX P28300 1/20 0.44
LMNA P02545 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.41
CYP1A2 P05177 1/20 0.39
PDE2A O00408 3/20 0.39
ALDH1A1 P00352 3/20 0.38
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
POLB P06746 1/20 0.35
TDP1 Q9NUW8 1/20 0.34
SLC6A3 Q01959 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10506569 0.87 SLC6A3 (0.47) LOXL2LOXLMNASMN1; SMN2CYP1A2
SCHEMBL13028821 0.79 LMNA (0.42) LMNASMN1; SMN2L3MBTL1CYP1A2PDE2A
SCHEMBL8343522 0.78 LMNA (0.45) LMNASMN1; SMN2L3MBTL1CYP1A2PDE2A
SCHEMBL13983020 0.76 TDP1 (0.44) LMNASMN1; SMN2L3MBTL1CYP1A2PDE2A
SCHEMBL15752122 0.76 LMNA (0.48) LMNASMN1; SMN2L3MBTL1CYP1A2PDE2A
SCHEMBL13738921 0.76 CYP1A2 (0.44) LMNASMN1; SMN2L3MBTL1CYP1A2PDE2A
SCHEMBL4595225 0.76 LMNA (0.43) LMNASMN1; SMN2L3MBTL1CYP1A2PDE2A
SCHEMBL10048775 0.76 LMNA (0.43) LMNASMN1; SMN2L3MBTL1CYP1A2PDE2A
SCHEMBL379405 0.76 SMN1; SMN2 (0.43) LMNASMN1; SMN2L3MBTL1CYP1A2PDE2A
SCHEMBL9226780 0.76 LMNA (0.43) LMNASMN1; SMN2L3MBTL1CYP1A2PDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116924999-A Preparation process of (4, 6-dimethoxy pyrimidine-2-yl) methylamine 河北诚信集团有限公司 2023-10-24 CN claimed
CN-116924999-A Preparation process of (4, 6-dimethoxy pyrimidine-2-yl) methylamine 河北诚信集团有限公司 2023-10-24 CN disclosed
CN-116924999-A Preparation process of (4, 6-dimethoxy pyrimidine-2-yl) methylamine 河北诚信集团有限公司 2023-10-24 CN disclosed
CN-116924999-A Preparation process of (4, 6-dimethoxy pyrimidine-2-yl) methylamine 河北诚信集团有限公司 2023-10-24 CN disclosed
US-20080293674-A1 Azinyl Imidazoazine and Azinyl Carboxamide BAYER CROPSCIENCE AG (DE) 2008-11-27 US disclosed
EP-1751152-A2 AZINYL IMIDAZOAZINE AND AZINYL CARBOXAMIDE Bayer CropScience Aktiengesellschaft (DE) 2007-02-14 EP disclosed
WO-2005113553-A2 AZINYL IMIDAZOAZINE AND AZINYL CARBOXAMIDE BAYER CROPSCIENCE AG (DE) 2005-12-01 WO disclosed
US-6576765-B2 Process for preparing amic acid esters IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2003-06-10 US disclosed
US-20030032667-A1 PROCESS FOR PREPARING AMIC ACID ESTERS IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2003-02-13 US disclosed
EP-1182199-A1 PROCESS FOR PREPARING AMIC ACID ESTERS IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 2002-02-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080293674-A1 Azinyl Imidazoazine and Azinyl Carboxamide AZI2, NISCH, ZYX LOXL2 3573/4885LOX 3737/4885LMNA 3030/4885
US-20030032667-A1 PROCESS FOR PREPARING AMIC ACID ESTERS MCCC2, EMC1, GANC LOXL2 2301/4885LOX 1199/4885LMNA 1532/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.