Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13230223 | 0.89 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNACYP1A2PDE2AKDM4E | |
| SCHEMBL8892697 | 0.87 | SLC6A3 (0.47) | SMN1; SMN2LMNACYP1A2ALDH1A1MEN1 | |
| SCHEMBL5502085 | 0.82 | LMNA (0.41) | SMN1; SMN2LMNAL3MBTL1CYP1A2PDE2A | |
| SCHEMBL8343522 | 0.78 | LMNA (0.45) | SMN1; SMN2LMNAL3MBTL1CYP1A2PDE2A | |
| SCHEMBL7009144 | 0.77 | NPC1 (0.40) | SMN1; SMN2LMNAKDM4EALDH1A1NPC1 | |
| SCHEMBL4595225 | 0.76 | LMNA (0.43) | SMN1; SMN2LMNAL3MBTL1CYP1A2PDE2A | |
| SCHEMBL10048775 | 0.76 | LMNA (0.43) | SMN1; SMN2LMNAL3MBTL1CYP1A2PDE2A | |
| SCHEMBL13738921 | 0.76 | CYP1A2 (0.44) | SMN1; SMN2LMNAL3MBTL1CYP1A2PDE2A | |
| SCHEMBL4918384 | 0.76 | LOXL2 (0.44) | SMN1; SMN2LMNAL3MBTL1CYP1A2PDE2A | |
| SCHEMBL15752122 | 0.76 | LMNA (0.48) | SMN1; SMN2LMNAL3MBTL1CYP1A2PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098060-A1 | MACROCYCLIC CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2026-04-09 | — | — | US | disclosed |
| US-20250388592-A1 | (AZA)SPIROHEPTANE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | REMYND N.V. (BE) | 2025-12-25 | — | — | US | disclosed |
| EP-4587443-A1 | MACROCYCLIC CFTR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2025-07-23 | — | — | EP | disclosed |
| EP-4568968-A1 | (AZA)SPIROHEPTANE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Remynd N.V. (BE) | 2025-06-18 | — | — | EP | disclosed |
| WO-2024056798-A1 | MACROCYCLIC CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-03-21 | — | — | WO | disclosed |
| WO-2024033479-A1 | (AZA)SPIROHEPTANE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | REMYND N.V. (BE) | 2024-02-15 | — | — | WO | disclosed |
| EP-2463277-B1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2017-11-08 | — | — | EP | disclosed |
| US-20170114075-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2017-04-27 | — | — | US | disclosed |
| US-9598396-B2 | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-21 | — | — | US | disclosed |
| US-9458178-B2 | Spiro-oxindole compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2016-10-04 | — | — | US | disclosed |
| US-20020025976-A1 | Thiazole compounds and pharmaceutical compositions for inhibiting protein kinases and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2002-02-28 | — | — | US | disclosed |
| EP-1181283-A1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000075120-A1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2000-12-14 | — | — | WO | disclosed |
| US-5821368-A | Method for preparing pyrimidin-2-ylacetic acid esters | LONZA AG (CH) | 1998-10-13 | — | — | US | disclosed |
| EP-0819680-A2 | Process for the preparation of esters of pyrimidin-2-acetic acid | LONZA AG (CH) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996041799-A1 | SULPHONAMIDES AS HERBICIDES AND PLANT-GROWTH REGULATORS | HOECHST SCHERING AGREVO GMBH (DE) | 1996-12-27 | — | — | WO | disclosed |
| EP-0353640-B1 | Heterocyclic N-acylsulphonamides, process for their preparation, agents containing them and their use as herbicides and plant growth regulators | HOECHST SCHERING AGREVO GMBH (DE) | 1995-04-12 | — | — | EP | disclosed |
| US-5186736-A | Pre- and postemergence | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-16 | — | — | US | disclosed |
| US-5053072-A | HETEROCYCLIC N-ACYLSULFONAMIDES, AND THEIR USE AS HERBICIDES OR GROWTH REGULATORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-01 | — | — | US | disclosed |
| EP-0353640-A2 | Heterocyclic N-acylsulphonamides, process for their preparation, agents containing them and their use as herbicides and plant growth regulators | Hoechst Schering AgrEvo GmbH (DE) | 1990-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114075-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | TRPV3, TRPV1, TRPC3 | SMN1; SMN2 289/4885LMNA 1296/4885L3MBTL1 2721/4885 |
| US-20260098060-A1 | MACROCYCLIC CFTR MODULATORS | CFTR, CLIC1, ARRB1 | SMN1; SMN2 4573/4885LMNA 2343/4885L3MBTL1 4158/4885 |
| US-20020025976-A1 | Thiazole compounds and pharmaceutical compositions for inhibiting protein kinases and methods for their use | BRAF, CDK2, CHUK | SMN1; SMN2 4704/4885LMNA 3774/4885L3MBTL1 4722/4885 |
| US-20250388592-A1 | (AZA)SPIROHEPTANE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | SNCA, CHRNA6, CHRNA5 | SMN1; SMN2 95/4885LMNA 183/4885L3MBTL1 2464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.