Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188176 | 0.89 | HRH3 (0.42) | EBPSIGMAR1DHCR7USP2LMNA | |
| SCHEMBL1689615 | 0.76 | EBP (0.42) | EBPSIGMAR1DHCR7USP2LMNA | |
| SCHEMBL1689612 | 0.76 | EBP (0.42) | EBPSIGMAR1DHCR7USP2LMNA | |
| SCHEMBL1689681 | 0.75 | EBP (0.39) | EBPSIGMAR1DHCR7USP2PTGDR2 | |
| SCHEMBL1689678 | 0.75 | EBP (0.39) | EBPSIGMAR1DHCR7USP2PTGDR2 | |
| SCHEMBL4145410 | 0.74 | EBP (0.38) | EBPSIGMAR1DHCR7USP2LMNA | |
| SCHEMBL4145406 | 0.74 | EBP (0.38) | EBPSIGMAR1DHCR7USP2LMNA | |
| SCHEMBL12507729 | 0.73 | MCHR1 (0.37) | EBPSIGMAR1DHCR7USP2LMNA | |
| SCHEMBL1689652 | 0.73 | NOTUM (0.64) | EBPSIGMAR1DHCR7PTGDR2LMNA | |
| SCHEMBL1689647 | 0.73 | NOTUM (0.64) | EBPSIGMAR1DHCR7PTGDR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140031378-A1 | INSECTICIDAL SPIRONINDANE DERIVATIVES | SYNGENTA CROP PROTECTION LLC | 2014-01-30 | — | — | US | disclosed |
| US-8354423-B2 | Insecticidal spironindane derivatives | SYNGENTA CROP PROTECTION LLC (US) | 2013-01-15 | — | — | US | disclosed |
| US-20080306101-A1 | Insecticidal Spironindane Derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2008-12-11 | — | — | US | disclosed |
| EP-1697327-A1 | INSECTICIDAL SPIROINDANE DERIVATIVES | Syngenta Participations AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058836-A1 | INSECTICIDAL SPIROINDANE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306101-A1 | Insecticidal Spironindane Derivatives | NR1D1, NR1D2, NR1I3 | EBP 1034/4885SIGMAR1 22/4885DHCR7 406/4885 |
| US-20140031378-A1 | INSECTICIDAL SPIRONINDANE DERIVATIVES | NR1D1, NR1D2, NR1I3 | EBP 1034/4885SIGMAR1 22/4885DHCR7 406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.